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Clinical Trial Summary

As a phase I clinical research,this study plans to evaluate the safety and tolerability of CD70-targeting CAR-T cells in the treatment of CD70-positive advanced/metastatic solid tumors, and obtain recommended doses and infusion patterns.


Clinical Trial Description

This is a single-center, double-arm, open-label study. The research designs to follow 2 groups:Intravenous infusion group and Intraperitoneal injection group;each group sets up 2 phases,the first phase is dose discovery phase to obtain recommended doses,the second phase is dose expansion phase to verify the safety in the recommended doses. In the discovery phase,each group puts up 4 dose groups, adopting a dose-escalating 3+3 design, and plan to recruit about 12 subjects with CD70-positive advanced/metastatic solid tumors.In the dose expansion phase,each group will choose one or two dose groups to verify the safety and efficacy at this dose,and plan to recruit about 6 subjects in each dose group. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05468190
Study type Interventional
Source Chongqing Precision Biotech Co., Ltd
Contact Quanli Gao, M.D
Phone 15038171966
Email zlyygql0855@zzu.edu.cn
Status Recruiting
Phase Phase 1
Start date July 17, 2022
Completion date July 17, 2025

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