| Eligibility |
Inclusion Criteria:
1. Able to provide written informed consent and understand and agree to comply with the
requirements of this study as well as the assessment schedule.
2. Be at least 18 years of age on the date of signing the ICF.
3. Histopathologically confirmed esophageal squamous cell carcinoma: the clinical stage
is T1-2N1-3M0, T2 (diameter=3 cm) N0M0 or T3-4aN0-3M0 (stage II-IVA), and the staging
should be based on the AJCC 8th edition esophageal cancer staging system.
4. Patients are asked to provide an archival tumor tissue sample (FFPE tissue block or
approximately 15 [=6] freshly cut unstained FFPE sections) and a pathology report of
this baseline sample. If no archival sample is available or the sample is not
available, a biopsy sample is requested at baseline.
5. Prior to study enrollment, patients are evaluated by thoracic surgeon in charge of
surgery to verify that they meet the study requirements for R0 resection with radical
curative intent.
6. Cardiac and pulmonary function is good, and surgical resection for curative purposes
is confirmed, and cardiopulmonary function tests and respiratory or cardiology
consultation can be completed if necessary.
7. Measurable disease as assessed by the investigator according to RECIST version 1.1.
8. Eligible for anlotinib treatment.
9. ECOG performance status = 2 points.
10. = 14 days prior to enrollment, the following laboratory test values during the
screening period suggest that the patient has good organ function:
- Patient has not had a blood transfusion or use of growth factor supportive
therapy within =14 days prior to blood draw, when the following items are tested
prior to enrollment:
- Absolute neutrophil count = 1.5 x 109/L
- Platelet = 75×109/L
- Hemoglobin = 90 g/L
- Glomerular filtration rate (GFR) estimated by the Cooperative Equation for
Epidemiology of Chronic Kidney Disease =45mL/min/1.73 m2.
- Serum total bilirubin = 1.5 × upper limit of normal (ULN) (total bilirubin must
be <3 ×ULN in patients with Gilbert's syndrome).
- AST and ALT=2.5 ×ULN.
- Patients not receiving anticoagulant therapy: International normalized ratio or
activated partial prothrombin time = 1.5× ULN.
11. Females of childbearing potential must be willing to practice highly effective
contraception for the duration of the study, and for =120 days after the last dose of
cadonilimab or anlotinib, whichever occurs later, and have a negative urine or serum
pregnancy test result within =7 days prior to enrollment.
Exclusion Criteria:
1. Previous treatment for current esophageal cancer, including chemotherapy or
radiotherapy.
2. Prior receipt of antibodies or drugs targeting immune checkpoint pathways, including
but not limited to anti-cytotoxic T-lymphocyte-associated antigen-4 (anti-CTLA-4),
anti-PD-1, and anti-PD-L1 therapeutic antibodies.
3. Patients with non-squamous cell carcinoma.
4. Presence of locally advanced, unresectable disease, regardless of disease stage and
presence or absence of metastases (stage IV).
5. Active autoimmune disease or history of autoimmune disease that may recur.
Note: Patients with the following conditions do not need to be excluded and can
proceed for further enrollment screening:
- Well-controlled type I diabetes
- Hypothyroidism (as long as it is treated with hormone replacement therapy alone)
- Well-controlled celiac disease
- Skin conditions that do not require systemic treatment (e.g., vitiligo,
psoriasis, alopecia)
- Any other illness that is not expected to recur in the absence of an external
trigger
6. Any active malignancy in the = 2 years prior to enrollment, with the exception of the
specific cancers studied in this study and cancers that have recured locally after
radical therapy (e.g., resected basal cell or squamous cell skin cancer, superficial
bladder cancer, cervical or breast carcinoma in situ).
7. Any condition requiring systemic treatment with corticosteroids (prednisone or
equivalent> 10 mg/day) or other immunosuppressive medications within =14 days prior to
enrollment.
Note: Patients with current or prior use of any of the following steroid regimens do
not need to be excluded:
- Adrenal replacement steroids (prednisone or equivalent> 10 mg/day)
- Topical, ocular, intra-articular, intranasal, or inhaled corticosteroids with
very low systemic absorption
- Short-term (=7 days) prophylactic use of corticosteroids (e.g., contrast allergy)
or for the treatment of non-autoimmune diseases (e.g., delayed-type
hypersensitivity reactions caused by contact allergens)
8. Poorly controlled diabetes mellitus = 14 days prior to enrollment, or abnormal
laboratory test results of potassium, sodium, or corrected calcium > grade 1
(regardless of standard medical management) or = grade 3 hypoalbuminemia.
9. Has a history of interstitial lung disease, non-infectious pneumonitis, or poorly
controlled diseases, including pulmonary fibrosis, acute lung disease, etc.
10. Severe chronic or active infection requiring systemic antibacterial, antifungal or
antiviral therapy, including tuberculosis infection, etc. Severe infection within 4
weeks prior to enrollment, including but not limited to hospitalization for
complications of infection, bacteremia, or severe pneumonia.
11. Known history of HIV virus infection.
12. Patients with untreated chronic hepatitis B or HBV carriers with hepatitis B virus
(HBV) DNA = 500 IU/mL, or patients with active hepatitis C virus (HCV) should be
excluded.
Note: Patients with inactive hepatitis B surface antigen (HBsAg) carriers, treated and
stable hepatitis B carriers (HBV DNA < 500 IU/mL), and cured hepatitis C patients can
be enrolled.
13. Any major surgical procedure requiring general anesthesia = 28 days prior to
enrollment.
14. Previous allogeneic stem cell transplantation or organ transplantation.
15. Any of the following cardiovascular risk factors:
- Cardiogenic chest pain within 28 days prior to enrollment, defined as moderate
pain with instrumental limitation of activities of daily living.
- Symptomatic pulmonary embolism within 28 days prior to enrollment.
- Any history of acute myocardial infarction within 6 months prior to enrollment.
- Any history of heart failure consistent with New York Heart Association
Classification Class III or IV= 6 months prior to enrollment.
- Any = grade 2 ventricular arrhythmic event within 6 months prior to enrollment
(inclusive).
- Any history of cerebrovascular accident within 6 months prior to enrollment.
- Hypertension that remains uncontrolled with standard antihypertensive medication
within 28 days prior to enrollment.
- Syncope or seizures = 28 days prior to enrollment.
16. History of severe allergic reaction to chimeric or humanized antibodies or fusion
proteins.
17. Received any other chemotherapy, immunotherapy (e.g., interleukin, interferon,
thymosin), or any investigational therapy during the study period.
18. Patients who have not returned to baseline or stable levels of toxic side effects (due
to prior antineoplastic therapy) unless the AE is not considered to pose a safety risk
(e.g., alopecia, neuropathy, and specific laboratory abnormalities).
19. Received a live vaccine = 4 weeks prior to enrollment. Note: Seasonal influenza
vaccines are usually inactivated and are therefore permitted. Intranasal vaccination
is a live vaccine, so it is not allowed.
20. Has an underlying medical condition (including laboratory abnormalities) or
alcohol/drug abuse or dependence that, in the opinion of the investigator, is
detrimental to study drug administration or affects the interpretation of drug
toxicity or adverse events, or in the judgment of the investigator that the patient's
adherence during the study is not adequate that could affect compliance.
21. Participating in another therapeutic clinical study at the same time.
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