| Eligibility |
Inclusion Criteria:
- Subject who voluntarily participate and sign the informed consent form.
- Healthy male/female volunteers aged =18 and = 45 years.
- Body weight = 50.0 kg for men and = 45.0 kg for women, and body mass index (BMI) =18.5
and < 26.0 kg/m2.
- Able to comply with the lifestyle restrictions.
Exclusion Criteria:
- Subject has a history of allergy to any component of the investigational drug or
similar drugs, or allergic constitution.
- Subject has a current or past medical history that may affect the clinical trial or
dysfunction, including but not limited to the past or current respiratory system,
circulatory system, digestive system, urinary system, reproductive system, nervous
system, endocrine system, immune system, motor system, blood system, psychiatry/
psychology, dermatology and other clinically serious diseases or chronic diseases; or
any other diseases that may interfere with the test results.
- Any surgical condition or condition may significantly affect the absorption,
distribution, metabolism and excretion of the drug, or may pose a hazard to the
subjects.
- Subject has a history of surgery within 3 months prior to administration, or failure
to recover from surgery, or having an expected surgical plan during the trial.
- Subject has abnormal vital signs, laboratory abnormalities, and ECGs.
- Subject has used any of over-the-counter products within 7 days or prescription
medications within 28 days prior to dosing.
- Subject positive for hepatitis B surface antigen (HBsAg), hepatitis C antibody
(HCV-Ab), HIV antibody (HIV-Ab), or syphilis seroreactivity (Trust).
- Subject has a history of alcohol abuse within 1 year or positive alcohol breath test
results.
- Subject has a history of substance abuse within 1 year or a positive urine drug
screen.
- Subject who has daily smoking of = 5 cigarettes within 3 months.
- Subject who has special requirements for food, cannot comply with the unified diet or
have dysphagia.
- Subject who has consumption of special diet (such as grapefruit, chocolate, coffee,
xanthine-rich foods/drinks) within 48 hours prior to dosing and/or subject who has
excessive daily consumption of tea, coffee, grapefruit juice, caffeinated beverages
for nearly 3 months.
- Subject who has participated in other clinical trials within 3 months before
administration.
- Subject has used blood products or being blood donor or blood loss within 3 months.
- Pregnant, lactating women, or positive pregnancy test.
- Subject who refusal to contraception, or plan to donate sperm or ovums.
- Subject who has a history of needle or blood faintness.
- Subject directly involved in this clinical trial.
- Poor compliance or other conditions which would make participation in the study
unsuitable.
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