Male Infertility Due to Azoospermia Clinical Trial
Official title:
Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA
| Verified date | March 2024 |
| Source | Assiut University |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational [Patient Registry] |
- Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE). - Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular biopsy samples.
| Status | Not yet recruiting |
| Enrollment | 64 |
| Est. completion date | April 1, 2026 |
| Est. primary completion date | October 1, 2025 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Male |
| Age group | 18 Years to 45 Years |
| Eligibility | Inclusion Criteria: - Infertile males with normal volume, functional (non-obstructive) azoospermia. - Age: 18-45 years Exclusion Criteria: - Patients with proven obstructive azoospermia. - Cryptorchidism. - Testicular Agenesis and testicular atrophy. - Patient with exposure to gonadal toxins like chemotherapy, radiotherapy, and alkylating agents. |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Assiut University |
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Know more about the functional role of PGK2 and ACRV1 in the process of spermatogenesis. | 2 years | ||
| Primary | Detect if PGK2 and/or AVRV1 level can used as predictor for spermatogenesis in infertile men with non-obstructive azoospermia undergoing Testicular Sperm Extraction. | 2 years |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04053309 -
Round Spermatid Injection Protocol
|