Hypotension Drug-Induced Clinical Trial
Official title:
Incidence and Risk Factors Analysis of Acute Kidney Injury (AKI) After Intentional Hypotensive Anesthesia in Orthognathic Surgery Patients Following Enhanced Recovery After Surgery (ERAS) Guidelines
This project investigates intentionally hypotensive management such as NTG (nitroglycerin) or NTG+Trandate during general anesthesia in patients undergoing orthognathic surgery. Throughout the entire surgical procedure, blood biochemical and urine monitoring will be conducted. Serum creatinine (Cr) levels, urine analysis, and perioperative monitoring will be utilized as indicators for assessing renal function during the surgery. The objective is to assess its potential renal injury and identify early risk factors for acute kidney injury (AKI). Timely recognition of these factors will allow for the implementation of appropriate intervention strategies, aiding in the prevention of postoperative acute kidney injury. This approach contributes to achieving the goals of Enhanced Recovery After Surgery (ERAS) for surgical patients, promoting faster postoperative recovery.
Orthognathic surgery is currently a common procedure in oral and maxillofacial surgery. The facial region is composed of a complex and dense vascular network, requiring precise, accurate, and delicate surgical techniques on both hard and soft tissues. During intraoral procedures, the surgical field may be limited, making the management of surgical bleeding challenging. Controlled hypotension or hypotensive anesthesia is often employed during major maxillofacial surgeries to optimize conditions. Lowering blood pressure is advantageous as it helps reduce overall blood loss and improves the surgeon's visibility. Therefore, maintaining stable blood pressure within the ideal range during the surgical process is a critical anesthesia objective. This research emphasizes the prevention of acute kidney injury (AKI) in patients undergoing orthognathic surgery with intentional hypotension during general anesthesia. The goal is to detect the potential renal damage at an early stages, before a significant decline in kidney function occurs, thereby reducing the likelihood of acute kidney injury. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05970770 -
Hypotension Prediction Index vs Norepinephrine Infusion for Prevention of Spinal Hypotension for Cesarean Delivery
|
Phase 4 | |
| Recruiting |
NCT03626454 -
Norepinephrine Addition in Spinal Anesthesia of Caesarean Section
|
N/A | |
| Completed |
NCT03834454 -
Bupivacaine 5 mg vs 7.5 mg for Spinal Anesthesia in Cesarean Delivery in Indonesian Population
|
N/A | |
| Recruiting |
NCT05661942 -
Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate
|
Phase 4 | |
| Recruiting |
NCT05079269 -
Pre-op Fluid Study
|
N/A | |
| Completed |
NCT02967029 -
Effect of Controlled Hypotension on Cerebral Oxygen Saturation
|
Phase 4 | |
| Recruiting |
NCT06334549 -
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
|
Phase 4 | |
| Not yet recruiting |
NCT03478618 -
Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia
|
Early Phase 1 | |
| Not yet recruiting |
NCT03465943 -
Different Preloads for Prevention of Hypotension in Patients Undergoing Elective CS Under Intrathecal Anesthesia
|
Early Phase 1 | |
| Completed |
NCT05143684 -
Maternal Lateral Tilt and Cardiac Output in Caesarean Section
|
||
| Recruiting |
NCT03743870 -
Spinal Anesthesia in Caesarean Section
|
||
| Completed |
NCT02979405 -
Effectiveness of Phenylefrine in Prevention of Hypotension During Spinal Anesthesia for Cesarean Delivery
|
Phase 4 | |
| Completed |
NCT05101291 -
Fractional Spinal Anesthesia and Systemic Hemodynamics in Frail Elderly Hip Fracture Patients.
|
N/A | |
| Recruiting |
NCT04914234 -
Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries
|
Phase 4 | |
| Completed |
NCT05502146 -
Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension
|
Phase 4 | |
| Completed |
NCT05368376 -
Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries?
|
Phase 4 | |
| Completed |
NCT04865614 -
Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair
|