Clinical Trials Logo

Clinical Trial Summary

The aim of this study was to compare between crystalloid versus crystalloid and colloid combination preloads for prevention of hypotension following intrathecal anaesthesia in patients undergoing elective Caesarean section.

To examine weather baseline perfusion index could predict the incidence of intrathecal-induced hypotension during Caesarean section.


Clinical Trial Description

Intrathecal anesthesia is the most commonly used technique for elective Caesarean section all over the world.

One of the most common complications of this technique is hypotension. It's incidence is more than 80% without any prophylactic measures, this hypotension has adverse effects on both mother ( causing nausea and vomiting ) and foetus ( causing acidosis and neurological defects ).

This complication can be managed by several ways like fluid therapy, usage of vasopressors or combination between both of them.

Among the type of fluids ( crystalloid or colloid ) it's still not known which one of them is better. Crystalloid has a short intravascular half-life because of its rapid distribution into the interstitial space. On the other hand colloid remains longer within the intravascular space.

Change in baseline peripheral vascular tone due to pregnancy may affect the degree of such hypotension. The perfusion index ( PI ) derived from a pulse oximeter has been used for assessing peripheral perfusion dynamics due to changes in peripheral vascular tone. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03465943
Study type Interventional
Source Assiut University
Contact Essam E. Abd El-Hakeem, PhD
Phone 01207159716
Email Essam1993@yahoo.com
Status Not yet recruiting
Phase Early Phase 1
Start date March 2018
Completion date April 2019

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05970770 - Hypotension Prediction Index vs Norepinephrine Infusion for Prevention of Spinal Hypotension for Cesarean Delivery Phase 4
Recruiting NCT03626454 - Norepinephrine Addition in Spinal Anesthesia of Caesarean Section N/A
Completed NCT03834454 - Bupivacaine 5 mg vs 7.5 mg for Spinal Anesthesia in Cesarean Delivery in Indonesian Population N/A
Recruiting NCT05661942 - Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate Phase 4
Recruiting NCT05079269 - Pre-op Fluid Study N/A
Completed NCT02967029 - Effect of Controlled Hypotension on Cerebral Oxygen Saturation Phase 4
Recruiting NCT06334549 - A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia Phase 4
Not yet recruiting NCT03478618 - Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia Early Phase 1
Recruiting NCT06259760 - AKI Risk Factors Analysis After Intentional Hypotensive Anesthesia
Completed NCT05143684 - Maternal Lateral Tilt and Cardiac Output in Caesarean Section
Recruiting NCT03743870 - Spinal Anesthesia in Caesarean Section
Completed NCT02979405 - Effectiveness of Phenylefrine in Prevention of Hypotension During Spinal Anesthesia for Cesarean Delivery Phase 4
Completed NCT05101291 - Fractional Spinal Anesthesia and Systemic Hemodynamics in Frail Elderly Hip Fracture Patients. N/A
Recruiting NCT04914234 - Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries Phase 4
Completed NCT05502146 - Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension Phase 4
Completed NCT05368376 - Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries? Phase 4
Completed NCT04865614 - Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair