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Clinical Trial Summary

The presence of CKD has been linked to the development of HFpEF. Currently, the treatment for HFpEF is limited. SGLT2i are one of the few drug classes that have proven efficacy in HFpEF in randomized controlled trials. The results of mechanistic studies suggest that the benefits of SGLT2i on diastolic heart failure are independent of their glycosuric actions and may still be present in anuric subjects. Despite the significance of HFpEF in patients with CKD, patients with advanced kidney disease have been excluded from studies investigating anti-heart failure drugs. The effects of SGLT2i in patients under maintenance dialysis are largely unknown. Past pharmacokinetics and pharmacodynamics studies on empagliflozin in patients with end-stage renal disease (ESRD) demonstrated that the use of empagliflozin in patients with ESRD seemed safe, yet its efficacy remains to be explored.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT06249945
Study type Interventional
Source National Taiwan University Hospital
Contact Donna Shu-Han Lin, MD
Phone +886912902379
Status Not yet recruiting
Phase Phase 4
Start date February 1, 2024
Completion date December 31, 2030

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