Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Postoperative Atrial Fibrillation Clinical Trial

— ODFAPO  

Official title:

Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06054360
• Other study ID #: PI2023_843_0048
• Status: Recruiting
• Start date: April 17, 2023
• Est. completion date: November 2025

Study information

• Verified date: September 2023
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: Camille DAUMIN, MD
• Phone: 03 22 08 77 95
• Email: daumin.camille[@]chu-amiens.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The incidence of postoperative atrial fibrillation (POAF) after cardiac surgery is around 30%. POAF increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute myocardial infarction, and death. While the role of the left atrium (LAF) in the pathophysiology of POAF is now well-established, the part of the right atrium (RA) remains poorly understood. Recent studies suggest a correlation between RA function and POAF. RA function can be assessed by transthoracic echocardiography (TTE) with dedicated software for measuring the RA strain (RAS). RA function is thus divided into three phases: reservoir (RASr), conduit, and contraction. Numerous studies have demonstrated that a significant alteration in RAS predicts POAF in various clinical contexts. Therefore, it is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery. It is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 334
• Est. completion date: November 2025
• Est. primary completion date: November 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult patient (>18 years old)
• The patient was hospitalized at the Amiens University Hospital for scheduled aortocoronary bypass grafting under cardiopulmonary bypass.
• Echocardiographic image quality enabling the measurement of RAS parameters
• Patient affiliation to a social security scheme
• Patient/proxy information and collection of their non-opposition.

Exclusion Criteria:

• Patients participating in an interventional study may modify the incidence of POAF.
• History of atrial fibrillation or flutter.
• Valvular and ascending aorta cardiac surgery
• Urgent cardiac surgery.
• Presence of tricuspid insufficiency greater than grade 2.
• Left ventricular ejection fraction lower than 50%.
• Patient receiving circulatory mechanical assistance before surgery.
• Dependency on ventricular and atrial pacing by an internal or external cardiac pacemaker during the echocardiographic examination.

Related Conditions & MeSH terms

• Atrial Fibrillation
• Postoperative Atrial Fibrillation
• Sprains and Strains
• Strains

Locations

Country	Name	City	State
France	CHU Amiens Picardie	Amiens

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation of RASr parameter variation with POAF incidence	Correlation of RASr parameter variation with POAF incidence in patients undergoing postoperative cardiac surgery	30 months