| Eligibility |
Inclusion Criteria:
1. Women aged 18-70
2. Unilateral invasive carcinoma confirmed by histology (regardless of pathological type)
3. The initial diagnosis condition can be directly operated, without absolute surgical
contraindications
4. No gross or microscopic tumor remains after surgical resection
5. Adjuvant chemotherapy should be started within eight weeks after surgery
6. Patients with Hormone receptor-positive, HER2-negative (HR+HER2-), and positive
axillary lymph nodes =4
7. Definition of ER and Progesterone Receptor (PgR) positive: Positive ER for tumor cells
detected by immunohistochemistry is defined as ER positive , and positive PgR for
tumor cells detected as PgR positive .
8. There was no evidence of metastasis in clinical or imaging aspects during preoperative
examination
9. No peripheral neuropathy;
10. Eastern Oncology Collaborative Group (ECOG) physical status score: 0 or 1
11. Good postoperative recovery, at least 1 week interval between surgery
12. Adequate hematological and end-organ function as defined by the following laboratory
test results, which need to be completed within 28 days prior to the first study
treatment: absolute neutrophil count (ANC) = 1500 cells/µL (no granulocyte colony
stimulating factor (G-CSF) support therapy within 2 weeks prior to day 1 of course 1);
Lymphocyte count= 500 cells/µL; Platelet count= 100,000 cells/µL (no platelet
transfusion within 2 weeks before day 1 of course 1; hemoglobin= 9.0 g/dL; Aspartate
transferase (AST), Alanine aminotransferase (ALT), and alkaline phosphatase= 2.5 ×
upper limit of normal (ULN) serum total bilirubin = 1.0 × ULN; Patients with known
Gilbert disease and serum bilirubin levels = 3× ULN may be admitted; For patients not
receiving anticoagulant therapy: INR or activated partial thromboplastin time (APTT) =
1.5 × ULN within 28 days prior to initiation of study therapy; For patients receiving
anticoagulant therapy: a stable anticoagulant regimen within 28 days before the start
of study therapy and a stable International normalised ratio (INR); creatinine
clearance= 30 mL/min (calculated using the Cockcroft-Gault formula); Serum albumin =
2.5 g/dL
13. For women of childbearing age: agree to remain abstinent (avoid heterosexual
intercourse) or take an annual failure rate for at least 5 months during treatment and
at least 6 months after the last dose of docetaxel or epirubicin, or 12 months after
the last dose of cyclophosphamide, whichever occurs last < 1% of contraception. A
woman who is postmenopausal but has not yet reached postmenopausal status (menopause
lasts =for 12 consecutive months, for no reason other than menopause) and has not
undergone sterilization (ovarian and/or hysterectomy) is considered fertile.
14. Cardiac function: left ventricular ejection fraction (LVEF) >50% by ultrasound
examination
15. Sign the Informed Consent Form (ICF)
Exclusion Criteria:
1. Have a history of invasive cancer
2. T4 clinical tumors as specified in the Union for International Cancer Control/American
Joint Committee on Cancer tumor (UICC/AJCC) Tumor-Lymph Node Metastasis Classification
(8th Edition), including inflammatory breast cancer
3. For currently diagnosed breast cancer, prior systemic anticancer therapy (eg,
neoadjuvant therapy or adjuvant therapy) includes, but is not limited to,
chemotherapy, anti-HER2 therapy (eg, trastuzumab emtansine, pertuzumab, lapatinib,
neratinib or other tyrosine kinase inhibitors), hormone therapy, or anti-cancer
radiotherapy (RT), except for treatments planned under this study condition
4. Previous treatment with anthracyclines or taxane for any malignant tumor
5. History of ductal carcinoma in situ (DCIS) and/or lobular carcinoma in situ (LCIS),
treatment of ipsilateral breast cancer with systemic therapy, hormone therapy, or RT,
followed by invasive cancer, patients treated with DCIS/LCIS only surgery and/or RT
for contralateral DCIS may be enrolled in the study.
6. Prior to randomization, cardiopulmonary dysfunction according to any of the following:
history of NCI CTCAE v4.0 =3 symptomatic congestive heart failure or New York College
of Cardiology (NYHA) standard classification= II, angina requiring antianginal drugs,
severe arrhythmias not treated with appropriate medical therapy, severe conduction
abnormalities, or clinically significant valvular disease, high-risk, uncontrolled
arrhythmias (i.e., atrial tachycardia with > resting rate). 100/min, significant
ventricular arrhythmia [ventricular tachycardia], or high-grade atrioventricular (AV)
block [second-degree AV block type 2, or third-degree atrioventricular block]),
significant symptoms associated with left ventricular dysfunction, arrhythmia, or
myocardial ischemia (grade =2), myocardial infarction within 12 hours prior to
randomization; with uncontrolled hypertension (systolic blood pressure> 180 mmHg
and/or diastolic blood pressure > 100 mmHg; ECG findings show transmural infarction;
Oxygen therapy is required
7. Prior malignancy within 5 years prior to randomization, with negligible risk of
metastasis or death, except for malignancy that is expected to heal after treatment
(i.e., appropriately treated carcinoma in situ or basal or squamous cell skin cancer).
8. Known allergic or hypersensitivity to any component of the docetaxel, carboplatin,
cyclophosphamide, or epirubicin preparations; Allergic or hypersensitivity reactions
are known to filgrastim, pegfilgrastim, or granulocyte-macrophage colony-stimulating
factor (GM-CSF) preparations
9. Patients with serious infections (including but not limited to hospitalization due to
infectious complications, bacteremia, or severe pneumonia) that occurred within 4
weeks prior to initiation of study treatment, who received therapeutic oral or
intravenous antibiotics within 2 weeks prior to initiation of study treatment, and who
received prophylactic antibiotic therapy (such as prophylaxis for urinary tract
infection or prevention of chronic obstructive pulmonary disease) may be enrolled.
10. Pregnant or lactating women, or women planning to become pregnant during the study
period.
11. Poorly controlled hypertension (defined as: systolic blood pressure > 150 mmHg and/or
diastolic blood pressure >100 mmHg)
12. Mental illness, cognitive impairment, inability to understand the trial protocol and
side effects, and inability to complete the trial protocol and follow-up workers
(systematic evaluation is required before trial enrollment)
13. Persons without personal freedom and independent capacity for civil conduct.
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