| Eligibility |
Inclusion Criteria:
Participant Inclusion Criteria
Participants are eligible to be included in the study only if all the following criteria
apply:
Inclusion Criteria - phase II only
1. Histologically or cytologically confirmed diagnosis of HNSCC for which no standard
curative therapy is available.
2. No prior treatment with an anti-PD-1 antibody (e.g. nivolumab, pembrolizumab,
cemiplimab), as well as anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other
antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint
pathways.
3. Appropriate for single agent pembrolizumab.
1. Front line therapy for those whose tumors express PD L1 (CPS =1) OR
2. Front line therapy for those who cannot tolerate chemotherapy per the judgement
of the treating physician OR
3. As second line or greater line of therapy.
Inclusion Criteria - phase I only
1. Histologically or cytologically confirmed diagnosis of an invasive solid tumor
malignancy, for which no standard curative or life prolonging therapy is available OR
2. Meets all inclusion criteria above for the phase II study.
Inclusion Criteria - both safety and phase II
1. Male/female participants who are at least 18 years of age on the day of signing
informed consent.
2. A male participant must agree to use a contraception as detailed in Appendix 3 of this
protocol during the treatment period and for at least 120 days after the last dose of
study treatment and refrain from donating sperm during this period.
3. A female participant is eligible to participate if she is not pregnant, not
breastfeeding, and at least one of the following conditions applies:
1. Not a woman of childbearing potential (WOCBP) as defined in Appendix 3 OR
2. A WOCBP who agrees to follow the contraceptive guidance in Appendix 3 during the
treatment period and for at least 120 days after the last dose of study
treatment.
4. The participant (or legally acceptable representative if applicable) provides written
informed consent for the trial.
5. Have measurable disease based on RECIST 1.1. Lesions situated in a previously
irradiated area are considered measurable if progression has been demonstrated in such
lesions.
6. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1.
Evaluation of ECOG is to be performed within 21 days prior to the first dose of study
intervention.
7. Have adequate organ function as defined in the following table (Table 4). Specimens
must be collected within 14 days prior to the start of study intervention.
8. Able to swallow TT1-101 capsules whole.
Exclusion Criteria:
Participant Exclusion Criteria:
Participants are excluded from the study if any of the following criteria apply:
1. A WOCBP who has a positive urine pregnancy test within 72 hours prior to initiation of
treatment (see Appendix 3). If the urine test is positive or cannot be confirmed as
negative, a serum pregnancy test will be required.
2. Has received prior systemic anti-cancer therapy including investigational agents
within 3 weeks prior to initiation of treatment.
Participants must have recovered from all AEs due to previous therapies to = Grade 1
or baseline with the following exceptions: Participants with = Grade 2 neuropathy are
eligible. Participants with endocrine-related AEs Grade =2 requiring treatment or
hormone replacement are eligible.
3. Has received prior radiotherapy within 2 weeks of start of study intervention.
Participants must have recovered from all radiation-related toxicities, not require
corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted
for palliative radiation (=2 weeks of radiotherapy) to non-CNS disease.
4. Has received a live vaccine or live-attenuated vaccine within 30 days prior to the
first dose of study drug. Administration of killed or mRNA vaccines is allowed.
5. Is currently participating in or has participated in a study of an investigational
agent or has used an investigational device within 3 weeks prior to the first dose of
study intervention.
6. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to the first dose of study drug.
7. Has a known additional malignancy that is progressing or has required active treatment
within the past 3 years. Participants with basal cell carcinoma of the skin, squamous
cell carcinoma of the skin, or carcinoma in situ that have undergone potentially
curative therapy are not excluded.
8. Has known active CNS metastases and/or carcinomatous meningitis. Participants with
previously treated brain metastases may participate provided they are radiologically
stable, i.e. without evidence of progression for at least 4 weeks by repeat imaging
(note that the repeat imaging should be performed during study screening), clinically
stable and without requirement of steroid treatment for at least 14 days prior to
first dose of study intervention.
9. Has severe hypersensitivity (=Grade 3) to pembrolizumab and/or any of its excipients.
10. Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e., with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment and is allowed.
11. Has a history of (non-infectious) pneumonitis/interstitial lung disease that required
steroids or has current pneumonitis/interstitial lung disease.
12. Has an active infection requiring systemic therapy.
13. Human Immunodeficiency Virus (HIV)-infected (HIV1/2 antibody-positive) patients may
participate IF they meet all the following eligibility requirements:
1. They must be on an anti-retroviral regimen with evidence of at least two
undetectable viral loads within the past 6 months on this same regimen; the most
recent undetectable viral load must be within the past 12 weeks.
2. They must have a CD4 count =250 cells/mcL over the past 6 months on this same
antiretroviral regimen and must not have had a CD4 count <200 cells/ mcL over the
past 2 years, unless it was deemed related to the cancer and/or
chemotherapy-induced bone marrow suppression.
3. For patients who have received chemotherapy in the past 6 months, a CD4 count
<250 cells/mcL during chemotherapy is permitted as long as viral loads were
undetectable during this same chemotherapy.
4. They must have an undetectable viral load and a CD4 count =250 cells/mcL within 7
days of enrolment.
5. They must not be currently receiving prophylactic therapy for an opportunistic
infection and must not have had an opportunistic infection within the past 6
months.
14. Has a known active Hepatitis B (defined as Hepatitis B RNA detected) or known active
Hepatitis C virus (defined as HCV RNA is detected) infection.
15. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the study, interfere with the participant's
participation for the full duration of the study, or is not in the best interest of
the participant to participate, in the opinion of the treating investigator.
16. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
17. Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through 120 days
after the last dose of trial treatment.
18. Has had an allogenic tissue/solid organ or bone marrow transplant.
19. Significantly impaired cardiac function such as unstable angina pectoris, congestive
heart failure with New York Heart Association (NYHA) class III or IV, myocardial
infarction within the last 12 months prior to trial entry; signs of pericardial
effusion, serious arrhythmia (including QTc prolongation of >470 ms and/or pacemaker)
or prior diagnosis of congenital long QT syndrome or left ventricular ejection
fraction <50% on screening echocardiogram.
20. History of cerebral vascular accident or stroke within the previous 2 years.
21. Uncontrolled hypertension (>160/100mm Hg).
22. History of Grade 3 or 4 allergic reactions attributed to compounds of similar chemical
or biologic composition as TTI-101 (hydroxyl-naphthalene sulfonamides).
23. Previous treatment of the current malignancy with a STAT inhibitor.
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