The Relationships Between Personal Identity, Autobiographical Memory and Future Thinking in People With Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting Clinical Trial

— SELFSEP  

Official title:

The Relationships Between Personal Identity, Autobiographical Memory and Future Thinking in People With Multiple Sclerosis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05648292
• Other study ID #: 2022-A00495-38
• Status: Recruiting
• Start date: December 7, 2022
• Est. completion date: June 7, 2025

Study information

• Verified date: September 2023
• Source: Centre d'Investigation Clinique et Technologique 805
• Contact: Alexandra Ernst, PhD
• Phone: +33628496210
• Email: aernst[@]univ-paris8.fr
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Personal identity is composed of multiple facets of the self that are constructed and nourished through memories of past experiences (i.e., autobiographical memory) and the imagination of events that may occur in the future (i.e., future thinking) . While our previous work has shown that people with relapsing-remitting multiple sclerosis (pwRRMS) have autobiographical memory and future thought disorders, their impact on personal identity has not yet been explored. Based on a cognitive and clinical neuropsychology approach, this research project aims to better understand the cognitive mechanisms involved in the relationship between identity, autobiographical memory and future thinking in pwRRMS. We will examine the extent to which pwRRMS manage to maintain and reshape their identity through life experiences, with a particular interest in the potential integration of the disease as a facet of their identity. In addition, we will explore the positive and/or negative consequences of disease-related identity changes on emotional well-being and quality of life, as well as their links with the duration and severity of the disease. Overall, this research project will contribute to identify new therapeutic levers that can be used for the development of adapted and personalized care.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 90
• Est. completion date: June 7, 2025
• Est. primary completion date: December 7, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

For the clinical group:

Inclusion Criteria:

• Diagnosis of relapsing-remitting MS according to the McDonald's revised diagnostic criteria
• People aged between 18 and 55
• French native speaker
• Access to a computer or tablet, equipped with internet access, a camera and a microphone

Non-inclusion Criteria:

• MS relapse in the month prior to the inclusion
• Treatment with corticosteroids during the month preceding the inclusion
• Form of MS other than the relapsing-remitting form
• Neurological history (other than MS for patients), history or current presence of psychiatric disorders (e.g., depression, anxiety disorders, schizophrenia), substance abuse (e.g., alcohol, cannabis; past or present)
• Other diagnosed chronic pathology(ies) (other than MS for patients)
• Severe cognitive impairment
• Persons mentioned in Articles L1121-6 to L1121-8 in the French law (minors, persons deprived of liberty, adults subject to protective measures) For the control group:

Inclusion Criteria:

• People aged between 18 and 55
• Matched in age, gender and level in education
• French native speaker
• Access to a computer or tablet, equipped with internet access, a camera and a microphone

Non-inclusion Criteria:

• Neurological history (other than MS for patients), history or current presence of psychiatric disorders (e.g., depression, anxiety disorders, schizophrenia), substance abuse (e.g., alcohol, cannabis; past or present)
• Other diagnosed chronic pathology(ies) (other than MS for patients)
• Severe cognitive impairment
• Persons mentioned in Articles L1121-6 to L1121-8 in the French law (minors, persons deprived of liberty, adults subject to protective measures)

Related Conditions & MeSH terms

• Healthy Controls
• Multiple Sclerosis
• Multiple Sclerosis, Relapsing-Remitting
• Sclerosis

Intervention

Behavioral:
• Neuropsychological tests and psychological questionnaires
The clinical group will complete: the BCcogSEP: a comprehensive neuropsychological examination the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression The control group will complete: the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression

Locations

Country	Name	City	State
France	Hopital Raymond Poincaré Garches	Garches	Hauts De Seine

Sponsors (3)

Lead Sponsor	Collaborator
Centre d'Investigation Clinique et Technologique 805	ARSEP foundation, University Paris 8 Vincennes Saint Denis

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relationships between personal identity, autobiographical memory and future thinking	Scores obtained at the I AM and I WILL BE tasks assessing the access, qualitative properties of self-concepts, episodic richness and temporal organization of past and future events around self-concepts (between-group comparisons, pwRRMS versus control group)	15 days
Secondary	Relationships between personal identity, psychological functioning and clinical characteristics	Correlations between IAM and I WILL BE scores and scores obtained at the different questionnaires (BRIEF COPE, Connor Davidson Resilience Scale, Satisfaction with Life Scale, Hospital Anxiety and Depression Scale) Correlations between IAM and I WILL BE scores and level of functional disability (Expanded Disability Status Scale) Correlations between IAM and I WILL BE scores and disease duration	15 days