| Eligibility |
Inclusion Criteria:
1. 18-60 years (inclusive) at the time of signing the informed consent form, both men and
women;
2. Participants meet the 2015 international consensus diagnostic criteria for
neuromyelitis optica spectrum disease (NMOSD) and are AQP4-IgG positive or negative
(acceptable test results within 24 weeks before signing the informed consent form);
3. Experienced at least 2 attacks within 1 year before screening and/or at least 3
relapses in the past 24 months, but have at least 1 documented clinical evidence of
attack or relapse (including the first attack) within 12 months before screening;
4. Expanded disability status scale (EDSS) = 7.5 points at screening and baseline retest;
5. Participants voluntarily sign the informed consent form and voluntarily complete the
trial according to the protocol requirements.
Exclusion Criteria:
1. Pregnant or lactating female participants, or participants planning to have a child
during the study;
2. Any surgical procedure within 4 weeks before randomization, with evidence of other
demyelinating diseases or progressive multifocal leukoencephalopathy (PML);
3. Known active infection (excluding nail bed fungal infection or dental caries) within 4
weeks before randomization;
4. Hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCVAb), syphilis antibody,
or human immunodeficiency virus (HIV antibody) is positive;
5. History of drug or alcohol abuse or mental disorder within 1 year before
randomization;
6. Evidence of active tuberculosis (TB; excluding patients receiving drugs to prevent
latent TB infection);
7. Evidence of active interstitial lung disease;
8. Receipt of any live or live attenuated vaccine within 6 weeks before randomization;
9. History of malignancy, including solid tumors, hematological malignancies, and
carcinoma in situ (except completely resected and cured basal cell carcinoma and
squamous cell carcinoma or cervical carcinoma in situ) within the past 5 years;
10. History of severe drug allergy, allergy or intolerance to Mitoxantrone and liposomes
(shock, allergic reactions);
11. Participants with other chronic active immune system diseases other than NMOSD or
stable disease but requiring high-dose glucocorticoid maintenance therapy: such as
rheumatoid arthritis, scleroderma, Schogren' s syndrome, ulcerative colitis, genetic
immunodeficiency or drug-induced immunodeficiency; participants with positive
autoantibodies only but without clinical manifestations can be enrolled in the trial;
12. Participants with other diseases not suitable for this study as judged by the
investigator;
13. Received any investigational agent within 3 months prior to randomization, or
participated in a medical device clinical study and judged by the investigator to have
a potential impact on the results of this trial;
14. History of prior NMOSD therapy with any of the following: a. received prior
mitoxantrone or anthracycline therapy, total body irradiation, or bone marrow
transplantation at any time; b. received rituximab or any experimental B-cell
depleting agent within 6 months prior to randomization, unless the participant had a
B-cell count higher than LLN in the central laboratory; c. used any of the following
within 3 months prior to randomization:
Satralizumab,Tocilizumab,inebilizumab,Eculizumab,Alemtuzumab,Ciclosporin,Azathioprine,
Cyclophosphamide,Tacrolimus,Mycophenolate mofetil. Any other treatment to prevent
relapses in multiple sclerosis (MS) (eg, Interferon, Natalizumab, Glatiramer acetate,
Fingolimod, Teriflunomide, or Dimethyl fumarate); d. intravenous immunoglobulin (IVIG)
therapy, plasma exchange therapy (PE) within 1 month prior to randomization; e.
participants who are receiving oral corticosteroids at doses higher than 30 mg/day in
prednisolone conversion; f. anti-CD4, cladribine within 2 years prior to
randomization.
15. Presence of the following clinically significant diseases: a. cardiac ejection
fraction (EF) less than 50% by echocardiography or lower than the lower limit of
laboratory values at the study site; history of chronic congestive heart failure,
cardiac function NYHA class ? ~ ?; b. any of the following events within 3 months
before randomization: myocardial infarction, acute coronary syndrome, viral
myocarditis, pulmonary embolism, stroke; coronary revascularization within 6 months;
c. screening ECG showed QTc interval > 480 ms (according to Fridericia correction
formula, QTc = QT/RR^0.33), or a history of severe QTc prolongation.
16. Patients with the following abnormalities in laboratory values during screening: a.
aspartate aminotransferase (AST) > 3 × upper limit of normal (ULN), alanine
aminotransferase (ALT) > 3 × ULN, total bilirubin > 1.5 × ULN (unless due to Gilbert
's syndrome); b. platelet count < 50,000/µL (or < 50 × 10^9/L), hemoglobin < 9 g/dL
(or < 90 g/L), white blood cells < 2.0 × 10^3/µL, absolute neutrophil count < 1.0 ×
10^3/µL; c. creatinine clearance (CLcr) < 60 mL/min (calculated using the
Cockcroft-Gault formula: [140 - age (years)] × [body weight (kg)] × (0.85, if
female)/[72 × serum creatinine (mg/dL)]) or receiving dialysis during screening;
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