DNA Methylation Clinical Trial
Official title:
Whether Using DNA Methylome to Select Embryos Can Increase the Live Birth Rate During Assisted Reproductive Technology: A Multicenter, Randomized , Open-label Clinical Trial.
To determine whether using DNA methylome to select embryos can increase the live birth rate.
The rationale for the study is to establish the risk/benefit ratio of PIMS in women with in vitro fertilization (IVF) treatment, as DNA methylome is a potential biomarker in blastocyst selection in assited reproductive technology (ART). DNA methylation plays an important role during embryogenesis, global abnormal methylome reprogramming often occurs in human embryos, and DNA methylome pattern is associated with live birth rate. However, there is still no technology using DNA methylome as an indicator in preimplantation embryo screening. Recent paper reported that using Pre-implantation Methylome Screening (PIMS) can select embryos with better methylation state and euploid chromosomes. The efficiency of PIMS needs further validation through randomized clinical trial. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03642574 -
Preimplantation DNA Methylation Test (PIMT) in ART
|
N/A | |
Completed |
NCT03787849 -
Epigenetics in PostOperative Pediatric Emergence Delirium
|
N/A | |
Recruiting |
NCT05624827 -
The Role of FAM19A4 and Hsa-mir-124 Methylation in Predicting Prognosis of Untreated Cervical Intraepithelial Neoplasia 2 (CIN 2)
|
N/A | |
Completed |
NCT05085847 -
Effects of Mindfulness-based Intervention on Epigenetic Mechanisms, Cognition Function, Stress Response, and Well-being
|
N/A | |
Recruiting |
NCT04646954 -
DNA Methylation Testing for the Screening of Uterine Cervical Lesion
|
Phase 3 | |
Recruiting |
NCT04651946 -
Cell-free DNA Methylation for Epithelial Ovarian Cancer
|
Phase 2 | |
Recruiting |
NCT03961191 -
DNA Methylation for Screening Uterine Cervical Lesions: A Case-control Study
|
||
Not yet recruiting |
NCT05779904 -
Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
|
||
Recruiting |
NCT05791149 -
Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity
|
N/A | |
Recruiting |
NCT05801263 -
ctDNA Methylation for Epithelial Ovarian Cancer
|
||
Recruiting |
NCT05801276 -
ctDNA Methylation for Detecting Ovarian Cancer
|
||
Recruiting |
NCT05290415 -
Host DNA Methylation for Endometrial Cancer Screening
|
||
Recruiting |
NCT05290922 -
DNA CDO1 and CELF4 Methylation for Endometrial Cancer Screening
|
||
Recruiting |
NCT05290428 -
DNA PAX1 and JAM3 Methylation for Cervical Cancer Screening
|
||
Recruiting |
NCT03960879 -
DNA Methylation for Screening Uterine Cervical Lesions
|
||
Recruiting |
NCT05737953 -
Construction of Molecular Diagnostic Marker Model for Pancreatic Cystic Tumors Based on Pancreatic Cystic Fluid Samples
|
||
Recruiting |
NCT06140992 -
PaCIFiC-CUP Classifies Cancer of Unknown Primary
|
||
Completed |
NCT02032628 -
DNA Methylation and Cancer Prevention: Duration and Intensity of Exercise
|
N/A | |
Completed |
NCT04568512 -
DNA Methylation Biomarker for Diagnosis of Cholangiocarcinoma in Patients With Bile Duct Stricture
|
N/A | |
Completed |
NCT03227003 -
DNA Methylation and 1-C Metabolism Nutrient Intake
|
N/A |