Uterine Cervical Cancer Clinical Trial
Official title:
Utilization of DNA Methylation in the Screening of Uterine Cervical Lesions: A Case-control Study
The primary objective of this study is to compare the testing of DNA methylation, high-risk
HPV subtypes, and cytology with the definite histological results in a case-control study, so
as to determine the accuracy of DNA methylation in the screening of uterine cervical lesions.
This study will include 300 patients with definite histological results, with 100 of cervical
inflammation or low grade squamous intraepithelial lesions (LSIL), 100 of high grade squamous
intraepithelial lesions (HSIL), and 100 of uterine cervical cancer. All the cervical
specimens of cytology collected in the clinical settings will be utilized for the testing of
DNA methylation, high-risk HPV subtypes and thin prep liquid-based cytology test (TCT). The
sensitivity, specificity, positive predictive value and negative predictive value were
calculated based on the known histological results. The differences of DNA methylation with
high-risk human papillomavirus (HPV) and TCT will also be analyzed.
The testing of DNA methylation will be performed with the methylation-specific polymerase
chain reaction (PCR). The TCT and HPV testing will be performed with the Roche kits.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT01234480 -
Intended Use Study of the BD SurePath Plus™ Pap
|
||
| Completed |
NCT05022511 -
Three Birds With One Stone
|
N/A | |
| Recruiting |
NCT04857528 -
Detecting HPV DNA in Anal and Cervical Cancers
|
||
| Completed |
NCT01755897 -
A Multicenter, Prospective, Randomized Trial of Adjuvant Chemotherapy for Early-Stage Cervical Cancer Patients
|
N/A | |
| Recruiting |
NCT01667211 -
Clinical Study of Albumin-bound Paclitaxel Plus Nedaplatin in Cervical Cancer
|
Phase 2 | |
| Active, not recruiting |
NCT01226264 -
Diffusion MRI; Predictive Value for Cervical Uterine Cancer Recurrence
|
N/A | |
| Not yet recruiting |
NCT06254846 -
Evaluation of First-void Urine as an Alternative to Cervical Sampling for Human Papillomavirus (HPV) Testing in Cervical Cancer Screening (Single-center Study).
|
N/A | |
| Enrolling by invitation |
NCT01393470 -
Evaluation of Long-term HPV Vaccine Efficacy
|
N/A | |
| Terminated |
NCT00421096 -
Radiochemotherapy Followed by Adjuvant Chemotherapy Based on Gemcitabine in Uterine Cervical Cancer
|
Phase 2 | |
| Terminated |
NCT01284348 -
To Determine Safe and Effective Dose of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Participants With Advanced Non-small Cell Lung Cancer
|
Phase 2 | |
| Recruiting |
NCT03961178 -
A Cohort Study for the Following up of Conization
|
||
| Terminated |
NCT02317302 -
FDG Tumor Heterogeneity During Chemoradiation as a Predictor of Response in Patients With Cervical Cancer
|
Phase 1 | |
| Not yet recruiting |
NCT05824494 -
Cadonilimab Plus Nab -Paclitaxel for Patients With Recurrent, or Metastatic Cervical Cancer Resistant to Immune Checkpoint Inhibitors
|
Phase 2 | |
| Completed |
NCT00184093 -
Study of Gemcitabine and Concurrent Radiation Followed by Adjuvant Hysterectomy in Bulky Stage Ib and IIa Cervical Carcinoma
|
Phase 1/Phase 2 | |
| Recruiting |
NCT03960879 -
DNA Methylation for Screening Uterine Cervical Lesions
|
||
| Recruiting |
NCT04886700 -
Study of the SG001 Injection for Patients With Relapsed or Metastatic Uterine Cervical Cancer
|
Phase 2 | |
| Completed |
NCT02095119 -
A Monoclonal Antibody, Nimotuzumab, as Treatment for Recurrent or Metastatic Cervical Cancer
|
Phase 1/Phase 2 | |
| Enrolling by invitation |
NCT05231993 -
Clinical Triage and Treatment of Atypical Glandular Cells (AGC) Detected in Screening
|
N/A | |
| Recruiting |
NCT02036164 -
Adjuvant Chemotherapy for Locally Advanced Cervical Cancer
|
Phase 3 | |
| Recruiting |
NCT04974424 -
Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV
|