Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients

Acute Respiratory Distress Syndrome Clinical Trial

Official title:

Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05372731
• Other study ID #: BAL20220420
• Status: Not yet recruiting
• Phase: N/A
• Start date: November 30, 2022
• Est. completion date: December 30, 2022

Study information

• Verified date: October 2022
• Source: Southeast University, China
• Contact: ling liu, phD
• Phone: 86-25-83272201
• Email: liulingdoctor[@]126.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

ARDS caused by pneumonia is one of the main reasons for ICU admission in critically ill patients, and also a common complication in patients admitted to ICU with invasive mechanical ventilation. Bronchoalveolar lavage (BAL) is the main diagnostic method for these patients, which often leads to alveolar collapse and exacerbates hypoxemia. In clinical practice, recruitment maneuver (RM) is often used immediately after BAL to prevent such a situation, but there is a lack of data on RM after BAL.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: December 30, 2022
• Est. primary completion date: December 30, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Adult patients with invasive mechanical ventilation;

2. Patients who diagnosed with ARDS according to the Berlin definition

3. There are indications for bronchoalveolar lavage

Exclusion Criteria:

1. Patients with contraindications for EIT procedures;

2. Patients with contraindications for RM;

3. Previous chronic respiratory diseases (long-term home oxygen therapy for chronic respiratory diseases such as pulmonary fibrosis or COPD);

4. Pregnancy;

5. Refusal to sign informed consent

Related Conditions & MeSH terms

• Acute Lung Injury
• Acute Respiratory Distress Syndrome
• Respiratory Distress Syndrome
• Respiratory Distress Syndrome, Newborn

Intervention

Other:
• Recruitment Maneuver
RM after BAL

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Southeast University, China

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the ratio of tidal volume in the BAL side and the other side	distribution of tidal volume monitored by electrical impedance tomography from the BAL side to the other side	up to 24 hours
Secondary	partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio	partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio	up to 24 hours
Secondary	respiratory system compliance (the tidal volume to the driving pressure ratio)	respiratory system compliance was calculated by dividing expiratory tidal volume by the driving pressure (plateau pressure minus positive end-expiratory pressure)	up to 24 hours