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Clinical Trial Summary

This study employs a 2-stage design that aims to evaluate the efficacy and safety of ENV- 101, a potent Hedgehog (Hh) pathway inhibitor, in patients with refractory advanced solid tumors characterized by loss of function (LOF) mutations in the Patched-1 (PTCH1) gene. Stage 1 of this study will enroll approximately 44 patients randomized between two dose levels. As appropriate, Stage 2 of the study will expand enrollment based on the results of Stage 1.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05199584
Study type Interventional
Source Endeavor Biomedicines, Inc.
Contact Endeavor Clinical Trials
Phone 1-858-727-3199
Status Recruiting
Phase Phase 2
Start date May 24, 2022
Completion date May 2024