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A Study of ZN-c3 and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer

Ovarian Cancer Clinical Trial

Official title:
A Phase 1/2 Dose-Escalation and Dose-Expansion Study of ZN-c3 in Combination With Niraparib in Subjects With Platinum-Resistant Ovarian Cancer

Clinical Trial Summary

This is a Phase 1/2 study to evaluate the safety, clinical activity, pharmacokinetics (PK), and pharmacodynamics (PD) of ZN-c3 in combination with niraparib in subjects with platinum-resistant ovarian cancer.

Clinical Trial Description

This is a Phase 1/2 open-label, multicenter study to evaluate the safety, clinical activity, PK, and PD of ZN-c3 in combination with niraparib in subjects with platinum-resistant ovarian cancer who have failed Poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05198804
Study type Interventional
Source K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Contact Project Director
Phone (858) 263-4333
Email medicalaffairs@zentalis.com
Status Recruiting
Phase Phase 1/Phase 2
Start date January 27, 2022
Completion date November 2023
View Details
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