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Clinical Trial Summary

- Parasitic infection is a serious public health problem throughout the world particularly in developing countries including Egypt. (Al-Mozan H.et al,2017). The individuals infected with helminthes are responding to the parasite infections by a specific Th2 type innate and adaptive immune responses.( Zakeri A.et al,2018).The Coronavirus Disease 2019 (COVID-19) pandemic has affected over 169 million people and caused the death of millions worldwide.COVID vaccines with up to 95% of efficacy and effectiveness have been developed and approved by the Food and Drug Administration (FDA), USA. (Wolfel R.et al.2020).-Moreover, it's reported that vaccination against SARS-Cov-2 may lead to Cytokine Storm Syndrome in some vaccinated people with release of large amounts of cytokines as (IFNγ, IL-12, TNFα).( Costela-Ruiz VJ.et al.2020).


Clinical Trial Description

- Parasitic infection is a serious public health problem throughout the world particularly in developing countries including Egypt. (Al-Mozan H.et al,2017). - Stool examination and CBC (complete blood count) are considered as the most easily, affordable and accessible diagnostic tool to suspect the presence of parasitic infection.( Kovalszki A.et al.2016 ). - One of the most important laboratory findings in many helminthic and protozoan infections is the high rate of peripheral blood eosinophilia.( Kovalszki A.et al.2016 ) . Giardia lamblia cause increased number of lymphocytes as (AlMozan H.et al,2017) . - The individuals infected with helminthes are responding to the parasite infections by a specific Th2 type innate and adaptive immune responses. The Th2 pattern cytokines predominate in long-term helminth infected individuals.( Zakeri A.et al,2018). - During chronic helminths infection, there is increased production of interleukin-4 (IL-4) and interleukin-10 (IL-10) as anti-inflammatory cytokines, as well as increased activation and expansion of eosinophils, mast cells and basophils.( Allen JE.et al.2011). - In addition, IFNγ have an important inflammatory role in many protozoan parasites as Cryptosporidia, Microsporidia, Entamoeba histolytica.(Sala´t J.et al.2004). - The Coronavirus Disease 2019 (COVID-19) pandemic has affected over 169 million people and caused the death of millions worldwide.COVID vaccines with up to 95% of efficacy and effectiveness have been developed and approved by the Food and Drug Administration (FDA), USA. (Wolfel R.et al.2020). - Moreover, it's reported that vaccination against SARS-Cov-2 may lead to Cytokine Storm Syndrome in some vaccinated people with release of large amounts of cytokines as (IFNγ, IL-12, TNFα).( Costela-Ruiz VJ.et al.2020). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05185778
Study type Observational
Source Assiut University
Contact
Status Not yet recruiting
Phase
Start date January 1, 2022
Completion date October 30, 2025