Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT05185778 |
| Other study ID # |
parasitism & COVID19 vaccines |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
April 1, 2022 |
| Est. completion date |
October 30, 2025 |
Study information
| Verified date |
March 2022 |
| Source |
Assiut University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
- Parasitic infection is a serious public health problem throughout the world particularly in
developing countries including Egypt. The individuals infected with helminths are responding
to the parasite infections by a specific Th2 type innate and adaptive immune responses. The
Coronavirus Disease 2019 pandemic has affected over 169 million people and caused the death
of millions worldwide. COVID vaccines with up to 95% of efficacy and effectiveness have been
developed and approved by the Food and Drug Administration (FDA), USA. Moreover, it's
reported that vaccination against COVID may lead to Cytokine Storm Syndrome in some
vaccinated people with release of large amounts of cytokines as (IFNγ, IL-12, TNFα).
Description:
- Parasitic infection is a serious public health problem throughout the world particularly
in developing countries including Egypt.
- Stool examination and CBC(complete blood count) are considered as the most easily,
affordable and accessible diagnostic tool to suspect the presence of parasitic
infection.
- One of the most important laboratory findings in many helminthic and protozoan
infections is the high rate of peripheral blood eosinophilia. Giardia lamblia cause
increased number of lymphocytes.
- The individuals infected with helminths are responding to the parasite infections by a
specific Th2 type innate and adaptive immune responses. The Th2 pattern cytokines
predominate in long-term helminth infected individuals.
- During chronic helminths infection, there is increased production of interleukin-4
(IL-4) and interleukin-10 (IL-10) as anti-inflammatory cytokines, as well as increased
activation and expansion of eosinophils, mast cells and basophils.
- In addition, IFNγ have an important inflammatory role in many protozoan parasites as
Cryptosporidium, Microsporidia, Entamoeba histolytica.
- The Coronavirus Disease 2019 pandemic has affected over 169 million people and caused
the death of millions worldwide. COVID vaccines with up to 95% of efficacy and
effectiveness have been developed and approved by the Food and Drug Administration
(FDA), USA.
- Moreover, it's reported that vaccination against COVID may lead to Cytokine Storm
Syndrome in some vaccinated people with release of large amounts of cytokines as (IFNγ,
IL-12, TNFα).
