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Circulating Tumor DNA (ctDNA) Monitoring in the Assessment and Prediction of the Efficacy of PARP Inhibitors (PARPi)

Metastatic Castration-resistant Prostate Cancer Clinical Trial

Official title:
Circulating Tumor DNA (ctDNA) Monitoring in the Assessment and Prediction of the Efficacy of PARP Inhibitors (PARPi)

Clinical Trial Summary

To evaluate the application value of customized ctDNA monitoring in efficacy assessment and prediction during PARPi treatment

Clinical Trial Description

This clinical study is an open-label, single-center, observational study to evaluate the application value of customized ctDNA monitoring in efficacy assessment and prediction during PARPi treatment in mCRPC patients. A total of 30 participants with second-line treatment failure will be registered in this study. Whole blood collection will be conducted during the treatment for ctDNA detection, homologous recombination repair (HRR) genes testing, personalized panel customization and whole exome sequencing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05116579
Study type Observational [Patient Registry]
Source Sun Yat-sen University
Contact Yonghong Li, M.D.
Phone +020-87343656
Email liyongh@sysucc.org.cn
Status Recruiting
Phase
Start date October 31, 2021
Completion date August 31, 2023
View Details
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