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Clinical Trial Summary

This Phase 2 study will investigate the safety and clinical activity of vudalimab (XmAb20717) alone or in combination with standard of care anticancer therapies in patients with metastatic castration-resistant prostate cancer (mCRPC) who have progressed on prior therapy.


Clinical Trial Description

Detailed Description: This is a Phase 2, open-label, multiple-dose, multiple-arm, parallel assignment study in patients with mCRPC who have progressed on prior therapy. It will enroll subjects into 1 of 5 molecularly defined cohorts based on the results of acceptable, documented prior diagnostic testing: - Cohort A: Aggressive variant prostate cancer (AVPCa) - Cohort B: Homologous recombination deficient (HRD)/cyclin-dependent kinase 12 (CDK12) biallelic loss tumors that have progressed on poly-adenosine diphosphate ribose polymerase inhibitors (HRD/CDK12 PARP Progressors) - Closed to Enrollment - Cohort C: HRD/CDK12 biallelic loss tumors, naive to PARP inhibitors (HRD/CDK12 PARP Naïve) - Closed to Enrollment - Cohort D: Microsatellite instability-high (MSI-H) or mismatch repair deficient (MMRD), or tumor mutational burden-high (TMB-H) tumors - Closed to Enrollment - Cohort E: No Targetable Mutations ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05005728
Study type Interventional
Source Xencor, Inc.
Contact Jolene Shorr
Phone 858-275-0004
Email jshorr@xencor.com
Status Recruiting
Phase Phase 2
Start date October 22, 2021
Completion date September 30, 2025

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