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Clinical Trial Summary

TransCon IL-2 β/γ is an investigational drug being developed for treatment of locally advanced or metastatic solid tumors. This is a first-in-human, open-label, Phase 1/2, dose escalation and dose expansion study of TransCon IL-2 β/γ as monotherapy or in combination therapy in adult participants with advanced or metastatic solid tumors. Given the unique PK profile enabled by the TransCon technology, TransCon IL-2 β/γ presents the opportunity to enhance the therapeutic index of current IL-2 therapy.


Clinical Trial Description

IL-2 is a key cytokine that directs the immune system through pleiotropic effects mediated by promoting expansion of both cytotoxic effector cells and Tregs. TransCon IL-2 β/γ is designed as a long-acting delivery prodrug of IL-2 β/γ, a potent cytokine signaling molecule, with the potential to improve the safety and efficacy of IL-2. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05081609
Study type Interventional
Source Ascendis Pharma A/S
Contact Ray Tam
Phone 650-374-9144
Email RTM@ascendispharma.com
Status Recruiting
Phase Phase 1/Phase 2
Start date January 11, 2022
Completion date August 2027

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