Heart Failure With Preserved Ejection Fraction Clinical Trial
Official title:
The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF
NCT number | NCT05068934 |
Other study ID # | 2020-09 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | October 12, 2020 |
Est. completion date | June 1, 2021 |
Verified date | September 2021 |
Source | Chongqing Medical University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients.
Status | Completed |
Enrollment | 93 |
Est. completion date | June 1, 2021 |
Est. primary completion date | February 1, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Adult aged >=18years old; - Diagnosed with HFpEF. Diagnostic criteria including: 1. left ventricular ejection fraction =50%; 2. with the symptoms and/or signs of heart failure; 3. BNP=35 pg/mL and/or NTproBNP=125 pg/mL; 4. at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction Exclusion Criteria: - LVEF less than 45% at any time; - Severe liver failure; - Primary pulmonary hypertension; - Age <18 years old. |
Country | Name | City | State |
---|---|---|---|
China | The First Affiliated Hospital of Chongqing Medical University | Chongqing |
Lead Sponsor | Collaborator |
---|---|
Dongying Zhang |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Epicardial Fat Tissue | Epicardial Fat Tissue by cardiac color Doppler ultrasound | On admission | |
Primary | Cardiac Function | Left ventricular diastolic function and right ventricular systolic function by cardiac color Doppler ultrasound | On admission |
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