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NCT05059769 Clinical Trial

Relationship Between Ambulatory Arterial Stiffness Index and Left Ventricular Diastolic Function in Patients With HFpEF

Heart Failure With Preserved Ejection Fraction Clinical Trial

Official title:
Relationship Between Ambulatory Arterial Stiffness Index and Left Ventricular Diastolic Function in Patients With HFpEF

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05059769
Other study ID # 2020-09-21
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date October 10, 2020
Est. completion date April 30, 2022

Study information
Verified date September 2021
Source Chongqing Medical University
Contact Zhang Dongying
Phone +8613608398395
Email zdy.chris@qq.com
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Ambulatory arterial stiffness index (AASI) is associated with arteriosclerosis and hypertension. There is no report on whether AASI is associated with left ventricular diastolic dysfunction in patients with HFpEF.

Description:

Heart failure with preserved ejection fraction (HFpEF) is related to various complications, such as hypertension, obesity and arteriosclerosis. Ambulatory arterial stiffness index (AASI) is associated with arteriosclerosis and hypertension. AASI is especially associated with left ventricular diastolic dysfunction in patients with hypertension. Patients with HFpEF have obvious left ventricular diastolic insufficiency. However, there is still no research investigating the the relationship between AASI and left ventricular diastolic dysfunction in patients with HFpEF.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date April 30, 2022
Est. primary completion date December 31, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Adult aged >=18years old; Diagnosed with HFpEF. Exclusion Criteria: LVEF less than 45% at any time; Severe liver failure; Other causes of shortness of breath, such as severe pulmonary disease or severe Severe valvular disease of the left heart; Chronically bedridden or incapacitated; Age <18 years old.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China The first affiliated Hospital of Chongqing Medical University Chongqing

Sponsors (1)
Lead Sponsor Collaborator
Dongying Zhang

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Left ventricular diastolic function the ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity(E/e') 1 day On admission
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