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INSULIN THERAPY DE-INTENSIFICATION WITH iGlarLixi — IDEAL  

Type 2 Diabetes Treated With Insulin Clinical Trial

Official title:
INSULIN THERAPY DE-INTENSIFICATION WITH iGlarLixi

Clinical Trial Summary

Intensive insulin therapy using multiple daily injections (MDI) constitutes the most intense type of regimen in type 2 diabetes mellitus (T2D). Although highly effective in lowering blood glucose, it can also increase the risk of hypoglycemia, promote weight gain and cause significant treatment burden for the patients. As demonstrated by a number of clinical studies, overtreatment is a common and generally unrecognized problem in patients with T2D; nevertheless, medication de-escalation is still infrequent in everyday clinical practice. IGlarLixi is a once-daily fixed-ratio combination (FRC) of a basal insulin and a glucagon-like peptide-1 receptor agonist (GLP-1 RA), which can offer similar efficacy in glucose control with lower rates of hypoglycemia and smaller weight gain that basal insulin regimens. The aim of our randomised, controlled study is to examine prospectively the safety and efficacy of de-escalating MDI regimens to iGlarLixi in T2D adult patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Type 2 Diabetes Treated With Insulin
Clinical Trial Details
NCT number NCT04945070
Study type Interventional
Source Institute for Clinical and Experimental Medicine
Contact Martin Haluzik, MD, DSc
Phone +420 261 36
Email halm@ikem.cz
Status Recruiting
Phase Phase 4
Start date July 2021
Completion date June 2023
View Details
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