Other Clinical Trial - STaged Interventional Strategies for Acute

Status Recruiting

Clinical Trial Summary

An investigator-initiated, randomized, multicenter, two-arm, open-label study of consecutive patients presenting with STEMI and MVD Objectives: The present study aimed to investigate the difference in all-cause mortality after in-hospital staged PCI versus out-hospital staged PCI for ST-segment elevated myocardial infarction （STEMI）patients with multi-vessel Disease（MVD） Background: In primary percutaneous coronary intervention for STEMI with MVD, complete revascularization has proved to reduce the risk of cardiovascular death and myocardial infarction. However, a strategy of nonculprit-vessel PCI with the goal of complete revascularization still not to be confirmed. Compare with in-hospital staged PCI, out-hospital PCI as a strategy of nonculprit-vessel PCI for STEMI patients with MVD might have be beneficial results.

Clinical Trial Description

A total of 1700 subjects with STEMI who met inclusion criteria and do not have any exclusion criterion will be randomized to in-hospital staged PCI group and out-hospital staged PCI group. After successful percutaneous coronary intervention for culprit lesion, all non-culprit vessel with significant lesion defined at least 80% diameter stenosis by visual estimation and accompanied by a QFR measurement of less than or equal to 0.80 will be performed complete revascularization. 1. Patients randomized to in-hospital staged PCI will have treated during the index procedure (7±3 days), after revascularization of the culprit lesion, all significant non-culprit coronary lesions. 2. Patients randomized to out-hospital staged complete revascularization will have treated during the index procedure only the culprit lesion, and they will be hospitalized in 30±15 days for complete revascularization of all significant non-culprit coronary lesions. ;

Study Design

Related Conditions & MeSH terms

Coronary Artery Disease
Infarction
Multi Vessel Coronary Artery Disease
Myocardial Infarction
Percutaneous Coronary Intervention
ST Elevation Myocardial Infarction
STEMI

Clinical Trial Details

NCT number	NCT04918030
Study type	Interventional
Source	Xiamen Cardiovascular Hospital, Xiamen University
Contact	Xiang Chen, Dr
Phone	18033997788
Email	Seanchenx@126.com
Status	Recruiting
Phase	N/A
Start date	February 11, 2021
Completion date	May 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT03959072` - Cardiac Cath Lab Staff Radiation Exposure
Not yet recruiting	`NCT05669222` - The FAVOR V AMI Trial	N/A
Recruiting	`NCT04566497` - Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.	N/A
Recruiting	`NCT05240781` - Zotarolimus vs Sirolimus Eluting Stent in High Bleeding Risk	N/A
Recruiting	`NCT03378934` - Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary Intervention	Phase 4
Not yet recruiting	`NCT06025071` - Residual Inflammatory Risk-Guided colcHicine in Elderly Trial	Phase 4
Withdrawn	`NCT04043091` - Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction	N/A
Completed	`NCT03085823` - The All-comers Sirolimus-coated Balloon European Registry
Completed	`NCT02837744` - Studying Hemostatic Effect of Axiostat® Dressing on Radial Access After Percutaneous Procedure
Completed	`NCT02044146` - A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk	Phase 2/Phase 3
Completed	`NCT03131271` - Effect of Ice Bag Application to Femoral Region on Pain in Patients Undergoing Percutaneous Coronary Intervention	N/A
Completed	`NCT01135667` - Prasugrel Versus Double Dose Clopidogrel to Treat Clopidogrel Low-responsiveness After PCI	Phase 4
Completed	`NCT01156571` - A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX)	Phase 3
Unknown status	`NCT00751491` - Clopidogrel Versus Adenosin in Non Urgent Percutaneous Coronary Intervention (PCI)	Phase 3
Completed	`NCT00725868` - Blood Endothelium Biomarkers to Predict Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention	N/A
Completed	`NCT03708588` - Chewed Versus Integral Pill of Ticagrelor	Phase 4
Completed	`NCT04163393` - R-One Efficiency For PCI Evolution With Robotic Assistance	N/A
Recruiting	`NCT05554588` - Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI	N/A
Recruiting	`NCT06080919` - Plaque Modification And Impact On Microcirculatory Territory After Drug-Coated Balloon Percutaneous Coronary Intervention (PLAMI).	N/A
Recruiting	`NCT05353140` - LAAO Versus NOAC in Patients With AF and PCI	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms