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NCT04773028 Clinical Trial

The Role of Matrix Metalloproteinase 2 and 9 Enzymes in Developing Chronic Thromboembolic Pulmonary Hypertension

Chronic Thromboembolic Pulmonary Hypertension Clinical Trial

Official title:
The Role of Matrix Metalloproteinase 2 and 9 Enzymes in Developing Chronic Thromboembolic Pulmonary Hypertension

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04773028
Other study ID # 2020-071
Secondary ID
Status Completed
Phase
First received
Last updated
Start date July 1, 2020
Est. completion date May 4, 2021

Study information
Verified date August 2021
Source Kartal Kosuyolu High Speciality Training and Research Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery.Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling. The clot formed in chronic thromboembolic pulmonary hypertension does not melt and turns into a fibrous state, it occludes the pulmonary artery.In this study, investigators aimed to investigate the role of matrix metalloproteinase enzymes in pulmonary arterial wall remodeling in patients with chronic thromboembolic pulmonary hypertension

Description:

Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery. Only 4% of patients with acute pulmonary embolism develop chronic thromboembolic pulmonary hypertension and acute pulmonary embolism or deep vein thrombosis is reported in the anamnesis of 75% of those with chronic thromboembolic disease. Therefore, the etiology of the disease is not clear. Altought many studies are done, especially the role of inflamation is emhasised underlie the disease. Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling. The clot formed in chronic thromboembolic pulmonary hypertension does not melt and turns into a fibrous state, it occludes the pulmonary artery.In this study, investigators aimed to investigate the role of matrix metalloproteinase enzymes in pulmonary arterial wall remodeling in patients with chronic thromboembolic pulmonary hypertension. Matrix metalloprotinase enzymes are known to play a role in atherosclerosis. This research will investigate whether there is atherosclerosis together with inflamattion in the background of chronic thromboembolic hypertension.

Recruitment information / eligibility
Status Completed
Enrollment 48
Est. completion date May 4, 2021
Est. primary completion date May 4, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Despite 3 months of anticoagulation therapy - mean pulmonary arterial pressure > 20 mmHg - pulmonary vasculary resistance > 3 wood - pulmonary capillary wedge pressure < 15 mmHg - perfusion defect in ventilation perfusion scintigraphy - pulmonary angiography or computed tomography angiography showing pulmonary artery occlusive lesions Exclusion Criteria: - Patients undergoing pulmonary thromboendarterectomy concomitant coronary bypass, carotid endarterectomy, aortic valve, ascending aorta, mitral valve, tricuspid valve, pulmonary valve surgery - Patients who have undergone surgical or percutaneous procedures due to atherosclerotic disease

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• matrix metalloproteinase enzymes 2 and 9
concentration of matrix metalloproteinase 2 and 9 enzymes

Locations
Country Name City State
Turkey Kartal Kosuyolu High Speciality Training and Research Hospital Istanbul Eyalet/Yerleske

Sponsors (1)
Lead Sponsor Collaborator
AHMET ZENGIN

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Concentration of Matrix Metalloproteinase 2 and 9 Enzymes Measurement the concentration of matrix metalloproteinase 2 and 9 enzymes by elisa and western blot techniques. 1 year
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