POCD - Postoperative Cognitive Dysfunction Clinical Trial
Official title:
The Effect of Ketamine and Dexmedetomidine on the Postoperative Cognitive Dysfunction After Cataract Surgery: Randomized Controlled Double-blinded Study
Verified date | April 2021 |
Source | Tanta University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
- Cataract surgery is commonly performed in elderly patients who are at high risk for developing postoperative cognitive dysfunction. Most cataract surgeries are performed under peribulbar or retrobulbar anesthesia, however, most of the patients require sedation to relieve the perioperative anxiety and induce amnesia. So, many sedative agents can be used especially benzodiazepines which may increase the risk of developing postoperative cognitive dysfunction. - Ketamine can be used as a sedative and analgesic agent in a dose of 0.25 -0.5 mg/kg with certain studies suggesting that it may decrease the risk of postoperative cognitive dysfunction. Similarly, dexmedetomidine can be used as a sedative and analgesic agent with the possibility of decreasing the incidence of postoperative cognitive dysfunction. - this controlled study will compare the effect of ketamine or dexmedetomidine on the POCD of patients undergoing cataract surgery.
Status | Completed |
Enrollment | 90 |
Est. completion date | April 15, 2021 |
Est. primary completion date | April 15, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years to 85 Years |
Eligibility | Inclusion Criteria: - Patients aged more than 65 years presented for cataract surgery under peribulbar anesthesia. Exclusion Criteria: - Patients with a history of psychological disorders as psychosis, schizophrenia, nephropathy. - Patients with uncontrolled medical conditions as D.M and hypertension. - Known allergy to the used medications - patients with hepatic, renal, or heart failure - Patients receiving anti-psychotic or anti-depressant medications. |
Country | Name | City | State |
---|---|---|---|
Egypt | Faculty of Medicine | Tanta | Algharbia Governate |
Lead Sponsor | Collaborator |
---|---|
Tanta University | Magrabi Hospital - Doha |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The postoperative cognitive function | Short Portable Mental Status Questionnaire (SPMSQ) It is a score system that depends upon the number of errors in 10 questions asked to the patient where; - 0-2 errors: normal mental functioning
3-4 errors: mild cognitive impairment 5-7 errors: moderate cognitive impairment 8 or more errors: severe cognitive impairment Mental Status Questionnaire (SPMSQ) score will be used to assess the cognitive dysfunction |
Within the first 3 days after surgery | |
Secondary | Change in the intraocular pressure | The IOP will be measured before the peribulbar anesthesia, min, 5 min and 10 min after peribulbar injection, then immediately after surgery. | Throughout the whole intraoperative period |
Status | Clinical Trial | Phase | |
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Recruiting |
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