Study the Role of SHMT1 Polymorphism in Parkinson Disease Clinical Trial
Official title:
Genetic Polymorphisms of Serine Hydroxylmethyl Transferase 1 (SHMT1) in Patients With Parkinson's Disease
| NCT number | NCT04706065 |
| Other study ID # | aswan |
| Secondary ID | |
| Status | Recruiting |
| Phase | |
| First received | |
| Last updated | |
| Start date | January 31, 2021 |
| Est. completion date | January 2022 |
Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system . SHMT has been shown to be associated with various diseases.
| Status | Recruiting |
| Enrollment | 80 |
| Est. completion date | January 2022 |
| Est. primary completion date | July 2021 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 50 Years and older |
| Eligibility | Inclusion Criteria: - Patients age = 50 years. - Patients with PD diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UK PDS Brain Bank diagnostic criteria) Exclusion Criteria: - Patients with parkinsonian plus syndrome - Patients with secondary parkinsonism - Patients with other chronic comorbidities (renal, hepatic, and endocrinal disturbances and chronic chest disease.) - Past and /or present history of epilepsy. - Patients with disturbed conscious level. |
| Country | Name | City | State |
|---|---|---|---|
| Egypt | Effat abdelhady tony | Assuit |
| Lead Sponsor | Collaborator |
|---|---|
| Assiut University | Aswan University Hospital |
Egypt,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | polymorphism of SHMT1gene | one year | ||
| Secondary | the role of SHMT1plymorphism in pathogenesis PD | one year | ||
| Secondary | Study the relationship of Shmt1 polymorphism to the severity of Parkinson disease | One year |