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Clinical Trial Summary

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Carcinoma
  • Carcinoma, Squamous Cell
  • Head and Neck Squamous Cell Carcinoma
  • Oropharyngeal Squamous Cell Carcinoma
  • Oropharynx Squamous Cell Carcinoma
  • Squamous Cell Carcinoma of Head and Neck

NCT number NCT04564989
Study type Observational
Source UNC Lineberger Comprehensive Cancer Center
Contact Chris Hilliard
Phone 919-966-4432
Email chris_hilliard@med.unc.edu
Status Recruiting
Phase
Start date November 19, 2020
Completion date November 2033

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