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Clinical Trial Summary

The objective of this project is to determine the extent to which administration of the dietary supplement phosphatidylserine (PS), a competitive inhibitor of ADAM17 sheddase activity, effects vascular function and insulin-stimulated leg blood flow in subjects with T2D.


Clinical Trial Description

As part of a randomized (2:1, experimental/placebo), double-blinded parallel design, each of the 34 subjects will complete 4 weeks (+/-4 days) of supplementation with either 900mg of a PS supplement or placebo. Assessment visits (2) will occur pre-intervention and post-intervention and include: 24-hour ambulatory blood pressure measurement (ABPM), Vitals, DEXA scan for body composition, fasting blood work, carotid-femoral pulse wave velocity (cfPWV), brachial and femoral artery FMDs, Femoral blood flow imaging during passive leg movement (PLM), glycocalyx integrity assessment via Glycocheck, and an oral glucose tolerance test (OGTT) with blood flow measurements and beat-to-beat sphygmomanometry via Finometer. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04557228
Study type Interventional
Source University of Missouri-Columbia
Contact Luis Martinez-Lemus, PhD
Phone (573) 882-3244
Email martinezlemusl@missouri.edu
Status Recruiting
Phase N/A
Start date March 17, 2023
Completion date November 1, 2025

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