MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer Clinical Trial
A Phase II Trial of AK104(PD-1 and CTLA-4 Bispecific Antibody) in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer During the Perioperative Period
This is a single-arm, multicenter phase II clinical study. The aim is to evaluate the safety, tolerability, and anti-tumor activities of AK104(a PD-1/CTLA-4 bispecific antibody) in MSI-H/dMMR locally advanced gastric adenocarcinoma and colorectal cancer during the perioperative period.Eligible patients will receive AK104 for three cycles before surgery and at most 6 months after surgery. The primary endpoint is the pathological complete response rate.
|Contact||Jiafu Ji, Professor|
|Status||Not yet recruiting|
|Start date||October 2020|
|Completion date||October 2023|