Effect of Arterio-venous ECMO on Severe Sepsis and ARDS
Patients With Respiratory Failure and Shocked Clinical Trial
Official title: The Immunoadsorption Effect of Arterio-venous ECMO in Refractory Septic Shock With ARDS Following Severe Lung Contusion
Clinical Trial Summary
To evaluate and compare the effect of immunoadsorption effect of A-V ECMO on course of sepsis
weaning from inotropes, weaning from the ventilator, duration of ICU stays and effect on
mortality rate in patients with septic shock and respiratory failure due to ARDS followed
severe lung contusion.
Clinical Trial Description
100 patients with respiratory failure without improvement after 10 days ventilation due to
development of VAP with ARDS, had >2 SOFA score and >6 CPIS score included in two groups 50
patients in each. Only patients of group B put on A-V ECMO while patients of group A continue
on traditional way of management. Improvement of ARDS &VAP, weaning from ventilation,
duration of ICU stays, improvement of one/all parameters of both SOFA and CPIS scores,
morbidity and mortality recorded and compared within 14 days.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
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Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
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