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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04192162
Other study ID # SRH BanjaKoviljaca
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date December 18, 2019
Est. completion date September 1, 2020

Study information

Verified date December 2019
Source Specialized Rehabilitation Hospital Banja Koviljaca
Contact Aleksandar M Jokic
Phone +381648731317
Email jokic71@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study is to examine the effects of sulfur bath and mud therapy on serotonin levels and other biochemical parameters in the blood of the osteoarthritis patients, as well as water the application of exercise in water effects the results we receive.


Description:

Sulfur baths and mud packs are known to have a positive effect in patients with osteoarthritis (OA). OA is a chronic degenerative disease accompanied by a constant pain that often leads to changes in the mood of patients. Over the last few decades, numerous articles reported various beneficial effects of sulfur water and peloid therapeutic applications. Serotonin is one of the important neurotransmitters that have numerous functions such as regulation of body temperature, sleep, appetite, while its main function is reflected in controling of depression.

The aim of this study is to examine the effects of sulfur bath and mud therapy on serotonin levels and other biochemical parameters in the blood of the OA patients, as well as whether the application of exercise in water effects the results we receive.

Randomized controlled study included patients with hip and/or knee OA both sexes, randomized into two groups. The first group patients underwent sulfur balneotherapy and mud pack therapy. Patients in the second group had sulfur balneotherapy, mud pack therapy and exercise in hygienic water. The duration of spa therapy program was 12 days. Serotonin values, parameters of complete blood count, lipid status and inflammatory markers were analyzed before and after the therapy.

This study is expected to be another contribution to existing evidence and shed light on the mechanisms of beneficial effects of balneotherapy and mud therapy and whether addition underwater exercise would have extra therapeutic effects.


Recruitment information / eligibility

Status Recruiting
Enrollment 60
Est. completion date September 1, 2020
Est. primary completion date April 18, 2020
Accepts healthy volunteers No
Gender All
Age group 50 Years to 65 Years
Eligibility Inclusion Criteria:

1. Ages of 50 - 65 , both sexes

2. Patients diagnosed with hip and / or knee OA without having used balneotherapy in the previous year

3. Patients who have not changed their medication in the last 2 months

4. Patients who have not received injections into the hip and / or knee joint in the last 6 months (PRP, Diprofos…)

Exclusion Criteria:

1. Secondary hip and / or knee OA

2. Patients with MOA inhibitors, selective serotonin inhibitors, morphine, lithium and methyldopa in therapy

3. Visible disruption of hip and / or knee joint structures

4. Treatment of malignancy

5. Diseases of the heart, lungs, decompensated conditions of other organs, infections, active bleeding

6. Severe hip and / or knee joint injuries, fractures, and previous surgical procedures

7. Physical therapy, balneotherapy back one year

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Mud therapy application
Aplication the mud pack therapy from 20 minutes
Sulfur water application
Aplication the sulfur water in bath from 20 minutes
Hygienic water
Exercise in hygienic water

Locations

Country Name City State
Serbia Specializd Rehabilitation Hospital Banja Koviljaca Loznica Banja Koviljaca

Sponsors (1)

Lead Sponsor Collaborator
Specialized Rehabilitation Hospital Banja Koviljaca

Country where clinical trial is conducted

Serbia, 

Outcome

Type Measure Description Time frame Safety issue
Primary The serotonin levels Serotonin concentration Time Frame: Baseline vs. 12-days
Secondary Marker of inflammation Sedimentation concentration Time Frame: Baseline vs. 12-days
Secondary Analysis of hemoglobin Concentration of hemoglobin (g/L) Time Frame: Baseline vs. 12-days
Secondary Analysis of red blood cell counts The total number of erythrocytes / L Time Frame: Baseline vs. 12-days
See also
  Status Clinical Trial Phase
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Not yet recruiting NCT03968770 - Probiotic for Pain Osteoarthritis N/A
Recruiting NCT04238143 - Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis N/A
Not yet recruiting NCT03985709 - Probiotic for Osteoarthritis N/A