Anterior Cruciate Ligament Rupture Clinical Trial
Official title:
Effect of Platelet Rich Plasma Injections on Inflammatory and Chondrodegenerative Biomarkers in Patients With Acute Anterior Cruciate Ligament Tears
A potential long-term consequence of anterior cruciate ligament injuries is the development of post-traumatic osteoarthritis in the years following injury. There are no curative treatments for osteoarthritis, increasing the importance of minimizing the occurrence of post-traumatic osteoarthritis following anterior cruciate ligament injuries. Current literature has begun to indicate that biochemical changes in the knee joint cartilage, such as chondrocyte death, following injury can contribute to the development of post-traumatic osteoarthritis. The main objective of this study is to determine if an early intervention of joint aspiration and platelet rich plasma injection will positively affect the biomarkers representative of chondral degeneration in patients with anterior cruciate ligament injuries. We hypothesize that the intervention will reduce the volume of inflammatory and chondrodegenerative biomarkers following anterior cruciate ligament injury.
A non-surgical treatment option for the management of osteoarthritis include injectables such as corticosteroids and platelet rich plasma. These injectables work by positively affecting cartilage cells, also known as chondrocytes, and the cells of the joint lining tissue, also known as synoviocytes. Platelet rich plasma is an autologous derived blood product, i.e. a joint injectable made from the patient's own blood at the time and location of injection with simple blood centrifugation. Studies in the bench-top laboratory setting have provided in-vitro evidence that platelet rich plasma decreases synoviocyte production of metallometal proteases, an inflammatory protein with negative effects on cartilage and decreases the effects of inflammatory proteins. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05487768 -
Functional Connectivity After Anterior Cruciate Ligament Reconstruction
|
N/A | |
| Recruiting |
NCT04390035 -
BFRT in Adolescents After ACL Reconstruction
|
N/A | |
| Recruiting |
NCT02740452 -
Anterior Cruciate Ligament Rupture
|
N/A | |
| Not yet recruiting |
NCT02555917 -
Comparison of Remnant Preserving Versus Remnant Resecting Anterior Cruciate Ligament Reconstruction
|
N/A | |
| Active, not recruiting |
NCT00529958 -
Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction
|
N/A | |
| Completed |
NCT05109871 -
Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque
|
N/A | |
| Not yet recruiting |
NCT06048874 -
FNB in ACL Recon Under SA
|
N/A | |
| Not yet recruiting |
NCT06048848 -
FNB in ACL Recon Under GA
|
N/A | |
| Terminated |
NCT03529552 -
Evaluation After Reconstruction of the Anterior Cruciate Ligament of the Knee Using the Bioresorbable Interference Screw (SMS): Resorbability, Per- and Post-operative Complications and Articular Functional Recovery.
|
N/A | |
| Completed |
NCT04285853 -
Are Opioids Needed After ACL Reconstruction
|
Phase 4 | |
| Active, not recruiting |
NCT03671421 -
Number One Overall Graft Pick? Hamstring vs Bone-Patellar-Tendon-Bone vs Quadriceps Tendon
|
N/A | |
| Not yet recruiting |
NCT04957706 -
Diagnostic Study of ACL Rupture With Anterior Drawer Test at 90° of Hip Flexion
|
||
| Not yet recruiting |
NCT04953676 -
A Clinical Trial of the Round-tunnel and Flat-tunnel Technique of ACL Reconstruction
|
N/A | |
| Enrolling by invitation |
NCT03365908 -
Pain Management of ACL Reconstruction
|
N/A | |
| Recruiting |
NCT06030791 -
BTB Graft Harvest and Donor Site Morbidity After ACL Reconstruction
|
||
| Recruiting |
NCT03950024 -
Improvement of Knowledge About the Arthrogenic Muscle Inhibition in the Aftermath of Knee Trauma.
|
N/A | |
| Recruiting |
NCT03229369 -
Association of ALL and ACL Reconstruction Versus Isolated ACL Reconstruction in High-risk Population: a RCT.
|
N/A | |
| Completed |
NCT01267435 -
Evaluation of Tibial and Femoral Tunnel Position After Arthroscopic Reconstruction of the Anterior Cruciate Ligament
|
Phase 2 | |
| Recruiting |
NCT06430775 -
Exploring Prolonged AMR in ACL Reconstructed Patients
|
||
| Completed |
NCT05057442 -
The Effects of Remnant-Preserving Anterior Cruciate Ligament Reconstruction on Proprioception and Functionality
|