Parkinson's Disease (PD) Clinical Trial
Official title:
A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of TD-9855 in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects With Primary Autonomic Failure
A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
Phase 3, multi-center, randomized withdrawal study to evaluate the sustained benefit in efficacy and safety of ampreloxetine in subjects with primary autonomic failures (MSA, PD, or PAF) and symptomatic nOH. The study consists of 3 periods: (i) 16-week open-label (OL) treatment with ampreloxetine, (ii) 6-week randomized placebo-controlled treatment, and (iii) 2-week follow-up (only for patients who do not enroll in Study 0171 (long-term extension safety study)). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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The Effect of BIA 9-1067 at Steady-state on the Levodopa Pharmacokinetics
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Phase 1 | |
| Completed |
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Pharmacokinetic-pharmacodynamic Interaction Between Each of Three Diferente Single Doses of BIA 9-1067 and a Single-dose of Immediate-release 100/25 mg Levodopa/Carbidopa
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Phase 1 | |
| Completed |
NCT02169895 -
Pharmacokinetic-pharmacodynamic Interaction Between Three Different Single Doses of BIA 9-1067 and a Single-dose of Immediate-release Levodopa/Benserazide
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Phase 1 | |
| Completed |
NCT02778594 -
Pharmacokinetic-pharmacodynamic Interaction Between BIA 3-202 and Levodopa/Benserazide
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Phase 1 | |
| Completed |
NCT02274766 -
Efficacy and Safety Study of ADS-5102 in PD Patients With Levodopa-Induced Dyskinesia
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Phase 3 | |
| Completed |
NCT02169453 -
Pharmacokinetic-pharmacodynamic Interaction Between Each of Three Different Single Doses of BIA 9-1067 and a Single-dose of Controlled-release 100/25 mg Levodopa/Carbidopa
|
Phase 1 | |
| Completed |
NCT04380142 -
Study Comparing Continuous Subcutaneous Infusion Of ABBV-951 With Oral Carbidopa/Levodopa Tablets For Treatment Of Motor Fluctuations In Adult Participants With Advanced Parkinson's Disease
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Phase 3 | |
| Withdrawn |
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Efficacy of Probiotics for Parkinson Disease (PD)
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N/A | |
| Recruiting |
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An Observational Study of Subcutaneous Infusion of ABBV-951 to Assess Change in Disease Activity and Adverse Events In Adult Japanese Participants With Advanced Parkinson's Disease
|
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| Completed |
NCT03033498 -
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Infusions of ABBV-951 in Subjects With Parkinson's Disease
|
Phase 1 | |
| Completed |
NCT02169427 -
An Open-label Study in Healthy Male Subjects to Assess the Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 9-1067 and Metabolites
|
Phase 1 | |
| Completed |
NCT02834507 -
Effect of Two Multiple-dose Regimens of BIA 3-202 on the Pharmacokinetics and Motor Response of Levodopa, and on the Erythrocyte Comt Activity in Parkinson's Disease Patients
|
Phase 2 | |
| Active, not recruiting |
NCT04379050 -
Extension Study To Evaluate Safety And Tolerability Of 24-Hour Daily Exposure Of Continuous Subcutaneous Infusion of ABBV-951 In Adult Participants With Parkinson's Disease
|
Phase 3 | |
| Completed |
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Effect of BIA 9-1067 on the Pharmacokinetics and Pharmacodynamics of Warfarin
|
Phase 1 | |
| Completed |
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Open-Label Safety Study of ADS-5102 in PD Patients With LID
|
Phase 3 | |
| Completed |
NCT01398748 -
Intranasal Glutathione in Parkinson's Disease
|
Phase 1 | |
| Recruiting |
NCT06107426 -
Real-World Study of ABBV-951 Subcutaneous Infusion to Assess Change in Disease Activity in Adult Participants With Parkinson's Disease
|
||
| Completed |
NCT02169466 -
Pharmacokinetic-pharmacodynamic Interaction Between Three Different Single Doses of BIA 9-1067 and a Single-dose of Controlled-release 100/25 mg Levodopa/Benserazide
|
Phase 1 | |
| Recruiting |
NCT03732898 -
Coordinated Reset Deep Brain Stimulation
|
N/A | |
| Completed |
NCT02799381 -
A Study Comparing Efficacy of Levodopa-Carbidopa Intestinal Gel/Carbidopa-Levodopa Enteral Suspension and Optimized Medical Treatment on Dyskinesia in Subjects With Advanced Parkinson's Disease (DYSCOVER)
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Phase 3 |