Contrast-induced Nephropathy Clinical Trial
Official title:
Effect of Allopurinol or Febuxostat to Prevent Contrast Induced Acute Kidney Injury (CI-AKI)
A randomized, placebo-controlled, double-blind clinical trial of effect of allopurinol or febuxostat to prevent contrast induced acute kidney injury (CI-AKI)
Eligible patients (patients with glomerular filtration rate < 60 ml/min or high riks patients
based on Mehran score) that will be undergoing cardiac catheterization/intervention randomly
assigned to receive allopurinol 300 mg or febuxostat 80 mg 12 hours before and 12 after 1
exposure of radiocontrast and IV hydration (normal saline 1 ml/kg/hr 12 pre and post
radiocontrast exposure) or placebo and hydration.
Exclusion criteria: patients under treatment with allopurinol or febuxostat in the previous
seven days, known allergy to allopurinol or febuxostat, patients on renal replacement therapy
;
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