The Effectiveness of Mini-fluid Challenge in Predicting Fluid Responsiveness During Video Assisted Thoracic Surgery

Mini-fluid Challenge in Video-Assisted Thoracic Surgery Clinical Trial

Official title:

The Effectiveness of Mini-fluid Challenge in Predicting Fluid Responsiveness During Video Assisted Thoracic Surgery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03731377
• Other study ID #: 201807009RINC
• Status: Recruiting
• Phase: N/A
• Start date: October 7, 2020
• Est. completion date: November 2021

Study information

• Verified date: October 2020
• Source: National Taiwan University Hospital
• Contact: Tzu Jung Wei
• Phone: +886972653416
• Email: sa46222[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.

Description:

Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. Fluid status and proper perfusion condition in patients undergo thoracic surgery are especially crucial for the vulnerability of lung toward fluid overload. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in video assisted thoracic surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: November 2021
• Est. primary completion date: November 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients receiving scheduled video assisted thoracic surgery

• BMI 18.5~30 kg.m-2

Exclusion Criteria:

• age younger then 20 yrs or elder than 80 yrs

• pregnant women

• patients in intensive care units

• patients with the underlying disease including respiratory failure(FEV1/FVC < 70 % and FEV1 < 50%), heart failure(NYHA score =III?IV), kidney failure(eGFR< 60 ml.min-1.1.73m-2), liver failure

• patients with ongoing infection

• patient allergic to voluven

Related Conditions & MeSH terms

• Aneurysm, Dissecting
• Mini-fluid Challenge in Video-Assisted Thoracic Surgery

Intervention

Drug:
• Crystalloid Solutions
Mini-fluid challenge with crystalloid 250 ml will be given to patients first. After observation of hemodynamic parameters, further fluid challenge will be given for response observation.

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

References & Publications (4)

Cavallaro F, Sandroni C, Antonelli M. Functional hemodynamic monitoring and dynamic indices of fluid responsiveness. Minerva Anestesiol. 2008 Apr;74(4):123-35. Epub 2008 Jan 24. Review. — View Citation

Evans RG, Naidu B. Does a conservative fluid management strategy in the perioperative management of lung resection patients reduce the risk of acute lung injury? Interact Cardiovasc Thorac Surg. 2012 Sep;15(3):498-504. doi: 10.1093/icvts/ivs175. Epub 2012 May 22. Review. — View Citation

Vincent JL. "Let's give some fluid and see what happens" versus the "mini-fluid challenge". Anesthesiology. 2011 Sep;115(3):455-6. doi: 10.1097/ALN.0b013e318229a521. — View Citation

Wyffels PA, Sergeant P, Wouters PF. The value of pulse pressure and stroke volume variation as predictors of fluid responsiveness during open chest surgery. Anaesthesia. 2010 Jul;65(7):704-9. doi: 10.1111/j.1365-2044.2010.06371.x. Epub 2010 May 6. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	stroke volume variation(SVV)	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3 hours
Other	stroke volume (SV)	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3 hours
Other	stroke volume index(SVI)	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3 hours
Other	plethysmographic variation index(PVI)	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3 hours
Other	pulse pressure variation(PPV)	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3 hours
Primary	Change of blood pressure after fluid loading	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3 hours
Secondary	Change of cardiac index after fluid loading	Interpretate the correlation of mini-fluid challenge and conventional fluid challenge	3 hours