Endothelial Dysfunction Clinical Trial
Official title:
Impaired Endothelial Glycocalyx Integrity and Arterial Elastic Properties in Patients With Embolic Stroke of Undetermined Source (ESUS)
Cardioembolism is a postulated mechanism of an embolic stroke of undetermined source (ESUS). The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS and age- and sex-adjusted healthy individuals.
The investigators aim to evaluate consecutive acute ischemic stroke (AIS) patients satisfying
ESUS diagnostic criteria in a single tertiary care stroke center (University Hospital,
Athens, Greece). Moreover, baseline characteristics and outcome measures for all AIS patients
are going to be recorded and further be classified, according to the Trial of Org 10172 in
Acute Stroke Treatment (TOAST) and ESUS criteria. Healthy volunteers (colleagues, friends,
relatives and others) will be included in the control group.
In participants (patients and controls) the investigators plan to measure: a) perfused
boundary region (PBR) of the sublingual arterial microvessels (range 5-25 micrometers), a
marker inversely related with glycocalyx thickness, b) pulse wave velocity (PWV), central
systolic blood pressure (cSBP) and augmentation index (AIx), c) LV Global Longitudinal strain
(GLS), d) LA volume and strain using speckle-tracking strain imaging, e) Malondialdehyde
(MDA), as an oxidative stress marker.
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