Chemotherapy Efficacy and Follow-up Study of Hepatitis B Virus Infection and Reactivation in Children With Leukemia

Reactivation of Hepatitis B Virus Clinical Trial

Official title:

Chemotherapy Efficacy and Follow-up Study of Hepatitis B Virus Infection and Reactivation in Children With Leukemia

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03529760
• Other study ID #: 2018-27
• Status: Recruiting
• Start date: May 8, 2018
• Est. completion date: May 30, 2020

Study information

• Verified date: July 2019
• Source: Children's Hospital of Chongqing Medical University
• Contact: Yao Zhao
• Phone: 86-23-6360-3083
• Email: Zhaoy[@]cqmu.edu.cn
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Children with clinically diagnosed leukemia may experience occult HBV infection after chemotherapy immunosuppressive therapy, which may affect the normal course of leukemia treatment. However, this is not caused by clinically relevant diagnosis and treatment measures but exists in vivo.

Description:

The clinical diagnosis of children with leukemia may be due to the influence of leukemia disease on the immune cells of the children and the damage to the immune system due to immunosuppressive therapy in children. Therefore, the risk of contracting hepatitis B virus is relatively high, and some children are In the treatment of immunosuppressive chemotherapy (later), the reactivation of occult HBV infection has an impact on the normal course of leukemia treatment. However, this is not a clinically relevant diagnosis and treatment measure. It is necessary to avoid unnecessary conflicts between clinical doctors and patients as much as possible.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 600
• Est. completion date: May 30, 2020
• Est. primary completion date: July 15, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 1 Year to 16 Years

Eligibility

Inclusion Criteria:

The clinical diagnosis of children with leukemia received systemic chemotherapy.

Exclusion Criteria:

Children with non-leukemia and children without appropriate treatment.

Related Conditions & MeSH terms

• Hepatitis
• Hepatitis A
• Hepatitis B
• Herpesviridae Infections
• Infection
• Leukemia
• Reactivation of Hepatitis B Virus
• Virus Diseases

Locations

Country	Name	City	State
China	Chongqing Children's Hospital of Chongqing Medical University	Chongqing	Chongqing

Sponsors (1)

Lead Sponsor	Collaborator
Children's Hospital of Chongqing Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	HBV-DNA positive	Positive HBV nucleic acid test	1-year