Hepatitis E Infection in Humans and in Environment Clinical Trial
— VHENEOfficial title:
Hepatitis E Infection : Emergence Mechanisms in North-Eastern France of Polymorphic Clinical Forms.
The present research aims to collect virological and clinical data on hepatitis E virus (HEV) infections, either in acute or chronic forms of HEV infection in North-Eastern France, with liver- or non liver-related symptoms, plus data on HEV circulation in the outside environment. The purpose of this study is to improve the diagnosis and care of HEV-infected patients, as well as the preventive features to take into account in order to avoid food- and environment-borne infections. At last, we will investigate HEV molecular characteristics, with the hypothesis that some advantageous HEV strains coul be more pathogenic for some tissues and/or organs.
| Status | Recruiting |
| Enrollment | 40 |
| Est. completion date | December 30, 2020 |
| Est. primary completion date | June 30, 2019 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - HEV-infected patients, with hepatitis and/or neurological and/or renal symptoms Exclusion Criteria: - Patients, with hepatitis and/or neurological and/or renal symptoms, infected by other viruses leading to hepatitis (hepatitis B, hepatitis C, hepatitis A ...) |
| Country | Name | City | State |
|---|---|---|---|
| France | Schvoerer | Vandoeuvre Les Nancy |
| Lead Sponsor | Collaborator |
|---|---|
| Central Hospital, Nancy, France |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Anti-HEV IgM (qualitative assay); | Guidelines to improve HEV detection by using the 2 virological assays | 2 years | |
| Primary | HEV RNA (quantitative PCR assay) | Guidelines to improve HEV detection by using the 2 virological assays | 2 years |