Effect of Orange Juice on Glycemic Response

Effect of Food on Postprandial Hyperglycemia Clinical Trial

Official title:

Effect of Hesperidin in Orange Juice on Glycemic Response in Healthy Volunteers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03522896
• Other study ID #: MEEC15-044b
• Status: Completed
• Phase: N/A
• Start date: September 30, 2017
• Est. completion date: June 27, 2018

Study information

• Verified date: June 2018
• Source: University of Leeds
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.

Description:

Healthy volunteers will consume orange juice with added water or food-grade hesperidin.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: June 27, 2018
• Est. primary completion date: June 27, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• fasting blood glucose below 5.9 mM

Exclusion Criteria:

• fasting glucose above 6 mM pregnant

Related Conditions & MeSH terms

• Effect of Food on Postprandial Hyperglycemia
• Hyperglycemia

Intervention

Other:
• control
balancing sugars and organic acids
• test meal 1
orange juice plus hesperidin low dose
• test meal 2
orange juice plus hesperidin higher dose
• test meal 3
diluted orange juice plus hesperidin low dose

Locations

Country	Name	City	State
United Kingdom	University of Leeds	Leeds

Sponsors (1)

Lead Sponsor	Collaborator
University of Leeds

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood glucose concentration	iAUC/[glucose]max	3 hours