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Natural History and Risk Factors of TAO

Thyroid Associated Ophthalmopathy Clinical Trial

Official title:
Natural History and Genetic Risk Factors of Thyroid Associated Ophthalmopathy (TAO)

Clinical Trial Summary

The aim of this study is to complete the identification of genetic factors predisposing to thyroid associated ophthalmopathy (TAO) by constituting a cohort of 400 Grave's patients with or without ocular signs.

Clinical Trial Description

Graves' disease (GD) is a common autoimmune condition, and its ocular condition is known as thyroid-associated ophthalmopathy (TAO). There is considerable evidence that both genetic and environmental factors are involved in the development of TAO. We conduct a study of 400 Grave's patients, with or without TAO, and obtain the following data: genetic tests, ocular imaging and life style information. Genetic tests are obtained by collection of blood samples for DNA extraction, whole-genome sequencing, and identification of cellular biomarkers, using transcriptomics and mass cytometry. Ocular imaging data are collected from Orbit MRI examination. Life style data are collected using a standardized questionnaire. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03515863
Study type Observational
Source Sun Yat-sen University
Contact Yingfeng Zheng
Phone +8613922286455
Email zhyfeng@mail.sysu.edu.cn
Status Recruiting
Phase
Start date May 15, 2018
Completion date May 9, 2022
View Details
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