Thyroid Associated Ophthalmopathy Clinical Trial
Official title:
Natural History and Genetic Risk Factors of Thyroid Associated Ophthalmopathy (TAO)
NCT number | NCT03515863 |
Other study ID # | 2017KYPJ123 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | May 15, 2018 |
Est. completion date | May 9, 2022 |
The aim of this study is to complete the identification of genetic factors predisposing to thyroid associated ophthalmopathy (TAO) by constituting a cohort of 400 Grave's patients with or without ocular signs.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | May 9, 2022 |
Est. primary completion date | May 9, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: 1. Patients of Grave's disease with the history of more than 1 years 2. Informed consent signed by a patient or legal guardian, or having the ability to comply with study assessments for the full duration of the study Exclusion Criteria: 1. Pregnancy (positive test) or lactation 2. Participating in another simultaneous medical investigation or clinical trial within 3 months 3. Having received cellular therapy 4. With a history of psychotropic drugs abuse 5. With a history of mental disorder 6. With a history of malignant tumor 7. Any medical or social condition that in the judgment of the investigator would interfere with or serve as a contraindication to adherence to the study protocol or ability to give informed consent |
Country | Name | City | State |
---|---|---|---|
China | Zhognshan Ophthalmic Center, Sun Yat-sen University | Guangzhou | |
China | the First People's Hospital of Zhaoqing | Zhaoqing |
Lead Sponsor | Collaborator |
---|---|
Sun Yat-sen University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Genetic risk factors of TAO predisposition | Genetic risk factors of TAO are identified by pathogenic gene screening using the whole-genome sequencing of peripheral blood cells. | 1 year | |
Secondary | Cellular biomarkers for risk of TAO | Cellular biomarkers for risk of TAO are identified by transcriptomics and mass cytometry | 1 year |
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