Microvascular Coronary Artery Disease Clinical Trial
Official title:
Study to Assess the Pharmacodynamic Effects of Repeated Oral Doses of SAR247799 on Endothelial Function in Male and Female Patients With Type 2 Diabetes Mellitus
Primary Objective: To assess the pharmacodynamic effects of SAR247799 on macrovascular endothelial function of the brachial artery using flow-mediated dilation (FMD) in patients with type 2 diabetes mellitus (T2DM). Secondary Objective: - To assess the pharmacodynamic effects of SAR247799 on microvascular endothelial function using laser Doppler perfusion monitoring in patients with T2DM. - To assess the safety profile of SAR247799 in patients with T2DM. - To assess the plasma pharmacokinetic profile of SAR247799 in patients with T2DM.
Study duration per patient is approximately 10 weeks including a 4-week treatment period. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT04069234 -
Study in Diabetes Mellitus Patients Without Prior Myocardial Infarction or Stroke Undergoing Elective Percutaneous Coronary Intervention.
|
Phase 3 | |
| Recruiting |
NCT04560829 -
Additive Value of Physiology Coronary in Clinical Practice
|
||
| Recruiting |
NCT06080919 -
Plaque Modification And Impact On Microcirculatory Territory After Drug-Coated Balloon Percutaneous Coronary Intervention (PLAMI).
|
N/A | |
| Terminated |
NCT04614467 -
A Placebo-Controlled Trial of CLBS16 in Subjects With Coronary Microvascular Dysfunction
|
Phase 2 | |
| Terminated |
NCT03236311 -
A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI
|
Phase 2 | |
| Recruiting |
NCT04598308 -
EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial
|
||
| Recruiting |
NCT04541797 -
Stress Cardiac Magnetic Resonance of Asymptomatic Type 2 Diabetics With Cardiovascular High Risk to Measure Empagliflozin Impact on Myocardial Blood Flow (CATCH-EM)
|
N/A | |
| Active, not recruiting |
NCT05197361 -
Microvascular Coronary Resistance and Absolute Coronary FLOW in Patients With Percutaneous Intervention of a Chronic Total Occlusion
|
||
| Recruiting |
NCT04827498 -
Myocardial Ischemia Without Obstructive Coronary Stenoses
|
||
| Suspended |
NCT05756088 -
Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA
|
||
| Recruiting |
NCT06118450 -
Clinical Trial for Evaluating the Effectiveness and Safety of Online caIMR in STEMI Patients
|
||
| Recruiting |
NCT03217227 -
Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR
|
||
| Not yet recruiting |
NCT06269874 -
Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment
|
N/A | |
| Not yet recruiting |
NCT06217120 -
Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
|
Phase 2/Phase 3 | |
| Recruiting |
NCT06316661 -
CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF
|
||
| Recruiting |
NCT04131075 -
The Cerebral-Coronary Connection (C3) Study
|
||
| Completed |
NCT04485234 -
Inclusive Invasive Physiological Assessment in Angina Syndromes Registry
|
||
| Completed |
NCT05471739 -
Simultaneous Assessment of Coronary Microvascular Dysfunction and Ischemia With Non-obstructed Coronary Arteries With Intracoronary Electrocardiogram and Intracoronary Doppler
|
||
| Completed |
NCT05406297 -
Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients
|
||
| Not yet recruiting |
NCT06069401 -
The MASTER-PACT Study
|