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Clinical Trial Details — Status: Available

Administrative data

NCT number NCT03419949
Other study ID # Comparison of oral lamotrigine
Secondary ID
Status Available
Phase
First received
Last updated

Study information

Verified date December 2019
Source Assiut University
Contact salma komy
Phone 01069572290
Email lolokoke@yahoo.com
Is FDA regulated No
Health authority
Study type Expanded Access

Clinical Trial Summary

Breast cancer is the most frequent neoplastic tumor in women, and surgical treatment is indicated in most patients. Complications related to this treatment, such as post-mastectomy pain syndrome (PMPS), a persistent pain that develops after surgery, have been reported. Although the genesis of the pain is multifactorial, sectioning of the intercostobrachial nerve is the nerve lesion diagnosed more often (1) ..

Pain relief using drugs with high efficacy provides significant improvement in the patients' lives. Drugs like lamotrigine (LTG) and gabapentin (GBP) have the ability to overcome the symptoms of neuropathic pain (4).

Both LTG and PGB have been extensively reviewed in the past for management of painful neuropathic conditions (5)


Description:

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Study Design


Related Conditions & MeSH terms

  • Acute and Chronic Pain Following Modified Radical Mastectomy
  • Chronic Pain

Intervention

Drug:
oral lamotrigine 100 mg
Pain relief drug Lamotrigine inhibits the voltage-gated sodium and calcium channels. Inhibition of the voltage-gated sodium channel stabilizes the presynaptic neuronal membrane, thus preventing the release of excitatory neurotransmitters such as glutamate and inhibiting sustained repetitive neuronal firing
oral pregabalin 150 mg
Pain relief using drug Pregabalin is a structural analogue of the inhibitory neurotransmitter gama-aminobutyric acid (GABA), with anticonvulsant, antihyperalgesic, and anxiolytic properties

Locations

Country Name City State
Egypt Salma Komy Assiut

Sponsors (1)

Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (14)

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