Newborn Infants With Enterostomy by Congenital Malformations of the Gastrointestinal Tract, Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Clinical Trial
Official title:
Proximal Remnant Intestinal Colonization in Newborn Infants With Enterostomy: a Longitudinal Study
The human microbiota, a collection of microorganisms mostly settled in the gastrointestinal
tract, plays a major role in the maintenance of the hosts' health and in development of
disease as well. Exposure to different conditions early in life contributes to distinct
"pioneer" bacterial communities, which shape the newborn infants' development and influence
their later physiological, immunological and neurological homeostasis. Newborn infants with
congenital malformations of the gastrointestinal tract (CMGIT), necrotizing enterocolitis
(NEC), and spontaneous intestinal perforation (SIP) commonly require abdominal surgery and
enterostomy. While intestinal microbiota has been extensively studied in infants with
anatomically uninterrupted intestine, the knowledge of longitudinal intestinal colonization
in this population is scarce.
This is an exploratory, observational, and longitudinal prospective study, primarily aimed to
determine longitudinally the colonization of the proximal remnant intestine, in newborn
infants with enterostomy after surgery (three weeks) for CMGIT, NEC and SIP. The secondary
aim is to explore the associations of the colonization with the mode of delivery, gestational
age, postnatal age, duration of fasting, type of enteric feeding, antimicrobial therapy,
H2-receptor antagonist therapy, and length of proximal remnant intestine.
n/a