Chronic Knee Joint Osteoarthritis Clinical Trial
Official title:
Ultra-sound Guided Saphenous Nerve Block Versus Platelet Rich Plasma for Chronic Knee Joint Osteoarthritis
| Verified date | September 2020 |
| Source | Mansoura University |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
Knee osteoarthritis, as a progressive disease is one of the most common causes of pain, motor
disorder and disability in the elderly. By increasing age, the cartilage is eroded and
endures degenerative changes due to physiological and biomechanical changes as well as
metabolic effects and trauma . Non-surgical interventions for pain control of knee
osteoarthritis include weight loss, exercise, changes in daily activities, physiotherapy,
nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics .However ,the intra-articular
injection is recently recommended by many studies such as corticosteroids, hyaluronic acid,
Growth hormone, dextrose ,and platelet rich plasma.
Intra-articular injection of platelets are activated and undergo degranulation, releasing a
range of growth factors, including transforming growth factor beta (TGF-β), platelet-derived
growth factor (PDGF), insulin-like growth factor, vascular endothelial growth factors,
epidermal growth factors and basic fibroblast growth factor 2. These growth factors are
thought to activate a variety of signaling pathways, which promote healing of bone and soft
tissue.Also,some minimally invasive therapeutic options have been effective in pain relieve
in KA, such as ultrasound-guided saphenous nerve block .
| Status | Completed |
| Enrollment | 56 |
| Est. completion date | September 30, 2018 |
| Est. primary completion date | August 1, 2018 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 45 Years and older |
| Eligibility |
Inclusion Criteria: - Patients who are not competent to understand the study protocol - Radiographic evidence of OA of knee of 2nd degree. - Chronic pain for at least 6 months prior to study entry (day 0). - Pain relief not achieved with conservative therapies during the last 6 months Exclusion Criteria: - Patient refusal. - Bleeding disorders. - Coagulation disorders. - Local skin infection - Current other problem in the affected extremity . - Psychiatric disorders affecting co-operation of the patient . - Previous chronic opioid use. - Intra articular knee injection within previous three months. - History of traumatic arthropathy. - History of neuropathic arthropathy. - Allergy or hypersensitivity to any of the study medication. - Any condition that could interfere with the interpretation of the outcome assessments. - Pregnancy - Lactating women. - low back pain due to central cause. |
| Country | Name | City | State |
|---|---|---|---|
| Egypt | Mansoura University Hospitals | Mansourah | DK |
| Lead Sponsor | Collaborator |
|---|---|
| Mansoura University |
Egypt,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Pain scores | The severity of pain will be assessed using a visual analog scale (VAS) | For 6 months after intervention | |
| Secondary | Quality of life (QOL) | is evaluated using the Western Ontario and MC Master universities (WOMAC) index of osteoarthritis | For 6 months after intervention |