Polyphenols and Risk of Dementia

Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology Clinical Trial

Official title:

Pattern of Polyphenol Intake and the Long-term Risk of Dementia in Older Persons

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03286608
• Other study ID #: Three-City study Bordeaux
• Status: Completed
• Phase: N/A
• First received: September 14, 2017
• Last updated: September 14, 2017
• Start date: January 1, 1999
• Est. completion date: December 31, 2015

Study information

• Verified date: September 2017
• Source: University of Bordeaux
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12 years following dietary assessment.

Description:

The study sample includes 1,329 subjects followed for up to 12 years fro dementia after dietary assessment. The aim is to identify a pattern of polyphenol intake (based on 26 flavonoid and non-flavonoid polyphenol subclasses ascertained using a 24-hour dietary recall) associated with the risk of dementia and AD over 12 years in the 3C Bordeaux cohort.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1329
• Est. completion date: December 31, 2015
• Est. primary completion date: December 31, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• 65 years or more, live in Bordeaux area (France)

Exclusion Criteria:

• with dementia at the time of dietary assessment in year 2001-2002

Related Conditions & MeSH terms

• Alzheimer Disease
• Dementia
• Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology

Intervention

Other:
• observational study (no intervention)
Statistical association between adherence to a pattern of polyphenol intake and the risk to develop dementia and Alzheimer's disease over 12 years

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Jean-François Dartigues

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	incidence of dementia	incident cases of dementia diagnosed by the expert committee of neurologists at follow-up visits	12 years
Secondary	incidence of Alzheimer's disease	dementia with probable or possible Alzheimer etiology	12 years