Role of RDW as Anon Invasive Index for Predicting Liver Cell Failure and Portal Hypertension in Cirrhotic Patient

Predicting Liver Cell Failure & Portal Hypertension in LC Clinical Trial

— RDW  

Official title:

Role of Red Cell Distribution Width as Anon Invasive Index for Predicting Liver Cell Failure and Portal Hypertension in Cirrhotic Patient

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03242135
• Other study ID #: 17100264
• Status: Recruiting
• Phase: N/A
• First received: August 4, 2017
• Last updated: August 7, 2017
• Start date: September 21, 2016
• Est. completion date: December 30, 2018

Study information

• Verified date: August 2017
• Source: Assiut University
• Contact: Marina Atef
• Phone: 01012767870
• Email: marina_atef_62[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

role of RDW as anon invasive method for predicting liver cell failure & portal hypertension in cirrhotic patient

Description:

Red blood cell distribution width (RDW) is a measure of the range of variation of red blood cell (RBC) volume. The RDW-SD (Standard deviation ) is an actual measure of size. Normal reference range of RDW-SD in adult human is 39-46 fL .Liver plays an important role in removing body toxins which affects RBCs ,so liver cirrhosis may affects the RDW. Cirrhosis is a chronic degenerative disease in which irreversible scarring of the liver occurs. It leads to liver failure. Child's score is used as an indicator for liver cell function Portal hypertension is an increase in the blood pressure within the portal venous system .Obstruction to blood flow that occurs in liver due to fibrosis and regenerating nodules reduce flow from the portal veins into the hepatic veins. It also impedes hepatic artery flow from the branches that feed into the sinusoids. This increase in arterial resistance leads to an increase in arterial flow into the portal vein via producing a new anastamosis. The net result of that is an increase in portal vein pressure and dilatation of portal vein. Direct measurement of portal pressure is invasive, inconvenient, and clinically impractical. The Hepatic Venous Pressure Gradient (HVPG) is used to measure portal pressure .Recently, portal vein diameter is used as indicator for portal hypertension .

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 30, 2018
• Est. primary completion date: February 21, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 17 Years to 90 Years

Eligibility

Inclusion Criteria:

The study will include a total of 100 patient in Assiut university hospital diagnosed to be cirrhotic by abdominal US. They will be divided into 3 groups according to Child's score (A,B,C)

Exclusion Criteria:

• Evidence of iron deficiency anaemia

• Patients within one month of hematemesis

• Thalassaemia

Related Conditions & MeSH terms

• Hypertension
• Hypertension, Portal
• Predicting Liver Cell Failure & Portal Hypertension in LC

Locations

Country	Name	City	State
Egypt	Marina Atef	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Role of RDW (red cell distribution width) as a non invasive index for predicting liver cell failure and portal hypertension in cirrhotic patient	To develop a simple predictive method for liver cell failure and portal hypertension in cirrhotic patient using the routine hematological parameters (RDW in complete blood count ) & abdominal US	3 years